Metformin Alleviates Autistic-Like Behaviors Elicited by High-Fat Diet Consumption and Modulates the Crosstalk Between Serotonin and Gut Microbiota in Mice

Figure 3

HFD and metformin increased sociability in the three-chamber test. (a) Experimental design for the three-chamber test for sociability/social novelty. (b) Mice from the HFD + vehicle and HBD + metformin groups spent significantly more time in the chamber with the unfamiliar conspecific, suggesting more sociability. (c) Mice from the HFD group showed significant preference for a novel over a familiar conspecific. Data are presented as the (). and compared with the control group.

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