Research Article
Metformin Alleviates Autistic-Like Behaviors Elicited by High-Fat Diet Consumption and Modulates the Crosstalk Between Serotonin and Gut Microbiota in Mice
Figure 4
HFD and metformin regulate the 5-HT pathway in the gut.(a–c) HPLC analysis of tryptophan, 5-HT, and the serotonin metabolite 5-HIAA levels in the colon. (d, e) Messenger RNA expression of tryptophan hydroxylase 1 (TPH1) and serotonin reuptake transporter (SERT) in the colon (). Data are presented as . . Trp: tryptophan; 5-HT: 5-hydroxytryptamine; 5-HIAA: 5-hydroxyindoleacetic acid.
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