Behavioural Neurology

Behavioural and Cognitive Changes in Neurodegenerative Diseases and Brain Injury


Status
Published

1University of Campania “Luigi Vanvitelli”, Naples, Italy

2National and Kapodistrian University of Athens, Athens, Greece

3Brain and Spine institut, Paris, France

4Pontificia Universidad Javeriana, Bogotá, Colombia

5University of Campania “Luigi Vanvitelli”, Caserta, Italy


Behavioural and Cognitive Changes in Neurodegenerative Diseases and Brain Injury

Description

Neurodegenerative diseases (NDs) comprise a wide range of neurological disorders with heterogeneous clinical and pathological manifestations, affecting/targeting distinct subsets of neurons in specific anatomic systems, thereby resulting in variable disease phenotypes. However, there is a considerable clinical and pathological overlap across NDs which has allowed for identifying some spectra of neurodegeneration, such as in case of tauopathies, synucleinopathies, Alzheimer’s disease (AD) pathology, and Tar-DNA binding protein (TDP) 43-proteinopathies. In this regard, (i) frontotemporal lobar degeneration (FTLD) may coexist with amyotrophic lateral sclerosis (ALS); (ii) Parkinson’s disease and Parkinsonian plus syndromes, such as corticobasal degeneration (CBD) and progressive supranuclear palsy (PSP) phenotypes, may present early cognitive and behavioural changes; (iii) FTLD may develop concomitant extrapyramidal symptoms; (iv) AD pathology can coexist with Lewy Body Disorders (LBD). On the other hand, patients with identical pathology can present with distinct clinical phenotypes. AD pathology is usually associated with progressive amnestic syndrome in elderly subjects. However, younger patients can show an atypical, focal, and clinical syndrome in which a single cognitive domain, not related to memory, is predominantly affected. Examples of such syndromes are the logopenic variant of primary progressive aphasia (lvPPA) and posterior cortical atrophy (PCA).

From the clinical point of view, behavioral changes are pervasive among a large array of neurodegenerative conditions, including AD and its atypical presentations, FTLD, ALS, PPA, DLB, PD, PSP, and CBD. However, behavioural changes are the clinical core of the behavioural variant of frontotemporal dementia (bvFTD), ranging from apathy to disinhibition, but are also frequently reported in ALS and Parkinsonian plus syndromes (DLB, CBD, and PD dementia). Furthermore, in favor of the emerging evidence of the disease continuum involving these neurodegenerative syndromes, it has been revealed that they show several overlapping genetic, neuropathologic, and neuroimaging signatures. Conversely, among the distinctive phenotypic characteristics within neurodegenerative proteinopathies, while loss of primary motor and executive functions is more commonly reported in both ALS and FTLD, an increasing detection of both extrapyramidal symptoms and cognitive changes, including executive and language dysfunctions, limb apraxia, and visuoconstructive deficits, has been described within the Parkinsonian plus syndromes. To note, behavioral and cognitive changes due to ischemic/hemorrhagic stroke or traumatic brain injury (TBI) may resemble the symptoms described in NDs, with transient or long-term effects. On the other hand, there are recent emerging evidences in favor of influence of AD-related proteins, such as β-amyloid peptide, hyperphosphorylated tau protein, presenilins, apolipoproteins, and secretases, on poststroke dementia and neuroinflammatory response to TBI. Finally, from the prognostic point of view, behavioral and cognitive impairment may have crucial implications on the quality of life of the patients and their caregivers during the whole course of the disease, significantly impacting the patients’ ability to engage competently in therapeutic and end-of-life decisions.

On this background, this special issue aims to bring a multidisciplinary perspective and updated insight into the most recent advances in the field of neuropsychology of neurodegenerative disorders, emphasizing the most appropriate and disease-specific psychometric tools for evaluating behavioral and cognitive impairments in the wide range of NDs, as well as in poststroke or TBI patients. Moreover, the impact of behavioral and cognitive abnormalities on the quality of life and prognosis of patients could also be addressed, giving some insights into the potential application of the early psychological interventions for reducing patients’ and caregivers’ distress. Neuroscientists from all over the world are invited to submit original research papers, clinical studies, and review articles.

Potential topics include but are not limited to the following:

  • Common or distinctive genetic, physiopathological, and neuroimaging correlates of behavioral and cognitive changes in NDs, poststroke, or TBI
  • Synaptic function and neural networks underlying behavioral and cognitive changes in NDs, poststroke, or TBI
  • Disease-specific psychometric tools for measuring behavioral and cognitive changes in NDs, poststroke, or TBI
  • Impact of behavioral and cognitive abnormalities on quality of life and prognosis of patients with NDs, poststroke, or TBI
  • Potential psychological interventions focused on behavioral and cognitive abnormalities of patients with NDs, poststroke, or TBI

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 4935915
  • - Editorial

Behavioural and Cognitive Changes in Neurodegenerative Diseases and Brain Injury

Francesca Trojsi | Foteini Christidi | ... | Gabriella Santangelo
  • Special Issue
  • - Volume 2018
  • - Article ID 4295184
  • - Clinical Study

COGEVIS: A New Scale to Evaluate Cognition in Patients with Visual Deficiency

Claire Meyniel | Dalila Samri | ... | Stéphane Epelbaum
  • Special Issue
  • - Volume 2018
  • - Article ID 1849794
  • - Review Article

Social Cognition Dysfunctions in Neurodegenerative Diseases: Neuroanatomical Correlates and Clinical Implications

Foteini Christidi | Raffaella Migliaccio | ... | Francesca Trojsi
  • Special Issue
  • - Volume 2018
  • - Article ID 7401465
  • - Research Article

Sentence Context and Word-Picture Cued-Recall Paired-Associate Learning Procedure Boosts Recall in Normal and Mild Alzheimer’s Disease Patients

Rosario Iodice | Juan José García Meilán | ... | Jeff A. Small
  • Special Issue
  • - Volume 2018
  • - Article ID 9684129
  • - Research Article

Functional Connectivity Changes in Behavioral, Semantic, and Nonfluent Variants of Frontotemporal Dementia

P. Reyes | M. P. Ortega-Merchan | ... | D. Matallana
  • Special Issue
  • - Volume 2018
  • - Article ID 5971385
  • - Research Article

The Effects of Transcranial Direct Current Stimulation on the Cognitive Functions in Older Adults with Mild Cognitive Impairment: A Pilot Study

Pablo Cruz Gonzalez | Kenneth N. K. Fong | Ted Brown
  • Special Issue
  • - Volume 2017
  • - Article ID 6137071
  • - Research Article

Effect of Voluntary Wheel Running on Striatal Dopamine Level and Neurocognitive Behaviors after Molar Loss in Rats

Linlin Zhang | Yi Feng | ... | Kun Liu
  • Special Issue
  • - Volume 2017
  • - Article ID 5181024
  • - Research Article

Subjective Cognitive Impairment, Depressive Symptoms, and Fatigue after a TIA or Transient Neurological Attack: A Prospective Study

Frank G. van Rooij | Nicole O. Plaizier | ... | Ewoud J. van Dijk
Behavioural Neurology
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Acceptance rate41%
Submission to final decision57 days
Acceptance to publication20 days
CiteScore2.900
Impact Factor2.093
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