Behavioural Neurology

Behavioural and Cognitive Changes in Lewy Body Dementias


Status
Published

Lead Editor

1Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan

2Chung Shan Medical University, Taichung, Taiwan

3Tokyo Women’s Medical University, Tokyo, Japan

4Kanazawa University Hospital, Ishikawa, Japan

5Chang Bing Show Chwan Memorial Hospital, Changhua County, Taiwan


Behavioural and Cognitive Changes in Lewy Body Dementias

Description

Dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) share many clinical and pathological features. They are therefore discussed together and referred to as Lewy body dementias (LBD). DLB may account for 10–15 percent of all cases of dementia. DLB can be diagnosed wrongly and is often mistaken for Alzheimer’s disease (AD) or PDD. Whether DLB and PDD are distinct disorders or whether they represent different stages of the same disease is an area of ongoing investigation. Symptoms of each disorder may arise from variations in regional and temporal onset of neural dysfunction and degeneration. By consensus, when cognitive impairments are coincident with or appear within 1 year of the motor signs, DLB is diagnosed; the term PDD is used when the decline occurs in the course of the well-established Parkinson’s disease (PD). Pathologically, both conditions are characterized by the presence of Lewy bodies and intraneuronal inclusions containing α-synuclein and ubiquitin in the brainstem, limbic area, forebrain, and neocortex.

Early signs of cognitive impairment in patients with LBD include executive dysfunction, visuospatial impairment, and deficits in verbal memory. Executive dysfunction is a hallmark feature of LBD and includes impairment in set shifting, attention, and planning. Memory deficits in LBD are to be related to the retrieval of learned information, which is improved by cueing. The most common extrapyramidal findings on examination in LBD are rigidity and bradykinesia, whereas other common signs are hypophonic speech, masked faces, stooped posture, and shuffling gait. Depression, anxiety, apathy, and fatigue commonly occur in LBD and are closely associated with cognitive decline. Detailed visual hallucinations frequently occur in both conditions as well. There are often overlapping visual hallucinations and other disorders of visual perception, including misidentification syndromes and visual agnosia. Auditory, tactile, or gustatory hallucinations may also occur but are less common. Visual hallucinations and delusions occur in up to 50% of patients with PDD, and their presence is strongly associated with cognitive dysfunction. Several drugs used in the treatment of PD, including anticholinergic agents, dopaminergic agents, and amantadine can exacerbate psychotic symptoms. In nondemented PD patients, those with hallucinations are more likely to develop dementia than patients without this symptom.

This special issue aims to bring a multidisciplinary perspective and updated insight into the most recent advances in the field of neuropsychology of neurodegenerative disorders, emphasizing the most appropriate and disease-specific psychometric tools for evaluating behavioural and cognitive impairments in the range of LBD. Moreover, the impact of behavioural and cognitive abnormalities on the quality of life and prognosis of patients could also be addressed, giving some insights into the potential application of the early psychological interventions for reducing patients’ and caregivers’ distress. Neuroscientists from all over the world are invited to submit original research papers, clinical studies, and review articles to us.

Potential topics include but are not limited to the following:

  • Common or distinctive biomarkers (genetic, physiopathological, and neuroimaging biomarkers, serum test, etc.) correlate with behavioural and cognitive changes in LBD
  • Synaptic function and neural networks underlying behavioural and cognitive changes in LBD
  • Disease-specific psychometric tools for measuring behavioural and cognitive changes in LBD
  • Potential psychological or pharmacological interventions focused on behavioural and cognitive abnormalities of patients with LBD
  • Population-based studies of pharmacological interventions, serum biomarker profiles, and psychometrics correlate with LBD

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 2404191
  • - Editorial

Behavioural and Cognitive Changes in Lewy Body Dementias

Woon-Man Kung | Ying-Jui Ho | ... | Cheng-Yu Wei
  • Special Issue
  • - Volume 2018
  • - Article ID 4618716
  • - Research Article

Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies

Ying-Jui Ho | Jun-Cheng Weng | ... | I-Yen Lee
  • Special Issue
  • - Volume 2018
  • - Article ID 5315098
  • - Research Article

Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies

Yao-Chin Wang | Po-An Tai | ... | Yu-Chuan (Jack) Li
  • Special Issue
  • - Volume 2018
  • - Article ID 8320901
  • - Review Article

Quality of Life in Patients with Dementia with Lewy Bodies

Chuo-Yu Lee | Shih-Jung Cheng | ... | Pei-Hao Chen
  • Special Issue
  • - Volume 2018
  • - Article ID 9421098
  • - Review Article

REM Sleep Behavior Disorder (RBD) in Dementia with Lewy Bodies (DLB)

Po-Chi Chan | Hsun-Hua Lee | ... | Dean Wu
  • Special Issue
  • - Volume 2018
  • - Article ID 6929732
  • - Research Article

Risk Factors for the Progression of Mild Cognitive Impairment in Different Types of Neurodegenerative Disorders

Pei-Hao Chen | Shih-Jung Cheng | ... | Chih-Ho Chou
  • Special Issue
  • - Volume 2018
  • - Article ID 8312346
  • - Research Article

Metabolic Risk Factors of Alzheimer’s Disease, Dementia with Lewy Bodies, and Normal Elderly: A Population-Based Study

Chih-Kuang Cheng | Yu-Chien Tsao | ... | Woon-Man Kung
  • Special Issue
  • - Volume 2018
  • - Article ID 7631951
  • - Research Article

Incidence and Comorbidity of Dementia with Lewy Bodies: A Population-Based Cohort Study

Sheng-Kung Yang | Weishan Chen | ... | Chung-Hsiang Liu
  • Special Issue
  • - Volume 2018
  • - Article ID 5802634
  • - Review Article

Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines

I-Chen Li | Li-Ya Lee | ... | Chin-Chu Chen
  • Special Issue
  • - Volume 2018
  • - Article ID 8420658
  • - Research Article

Glucose Metabolic Brain Network Differences between Chinese Patients with Lewy Body Dementia and Healthy Control

Danyan Chen | Jiaying Lu | ... | Chuantao Zuo
Behavioural Neurology
 Journal metrics
Acceptance rate41%
Submission to final decision57 days
Acceptance to publication20 days
CiteScore2.900
Impact Factor2.093
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