An Antithrombin-Heparin Complex Increases the Anticoagulant Activity of Fibrin Clots
Figure 1
Catalysis of thrombin inhibition by anticoagulant bound to purified fibrin. Thrombin on fibrin was mixed with antithrombin (AT) + heparin (H) or covalent antithrombin-heparin (ATH) and ability to accelerate reaction of additional thrombin + AT determined as the decrease in percent thrombin activity remaining compared to experiments without H or ATH. Data are expressed as mean ± SEM and n ≥ 6., using a t-test relative to ATH.
