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Biochemistry Research International
Volume 2010, Article ID 361387, 5 pages
Review Article

Hyperhomocysteinaemia in Behçet's Disease

Department of Internal Medicine, Fattouma Bourguiba University Hospital, 5000 Monastir, Tunisia

Received 18 January 2010; Accepted 15 February 2010

Academic Editor: R. J. Linhardt

Copyright © 2010 Amira Hamzaoui et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. The aim of this study was to investigate if hyperhomocysteinaemia is a contributive risk factor for the pathogenesis and the activity of Behçet's disease (BD). Design and Methods. Fifty four patients fullfiling the criteria of the International Study Group for BD were enrolled. Fifty healthy volunteers matched for age and sex with the BD group were included as a negative control group. Patients, with any condition that might affect plasma homocysteine concentration, were excluded. Results. Mean serum homocysteine concentration was significantly higher in patients with BD than in the healthy controls ( 𝑃 < . 0 0 1 ), in patients with active disease ( 𝑃 = . 0 4 ), and in masculine gender ( 𝑃 = . 0 5 ). There was no significant difference between homocysteine level and clinical involvement. Conclusions. We demonstrated that plasma total homocysteine level (tHcy) is increased in BD and correlated with disease activity. No association was found between homocysteine levels and clinical involvement.