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| Gene/name | cDNA | Expression in normal tissues |
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| MMP-14 (MT1-MMP) | Isolated from a human placenta cDNA library [73] | Highly expressed in ossifying tissues and during mouse embryogenesis, where it is coexpressed with MMP-2 [74]. Low expression in normal conditions. |
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Type I transmembrane MMPs | MMP-15 (MT2-MMP) | Isolated from a mouse lung cDNA library [75] | Highly expressed in T cells [76], rat smooth muscle cells [77], and endothelial cells [78]. Expressed in hepatocytes and biliary epithelial cells [79], in cytotrophoblasts [80], in activated NK-cells [81], and in microglial cells [82]. |
| MMP-16 (MT3-MMP) | Isolated from placenta cDNA library [63] | Expressed in human brain tissues (microglial cells) [62]; T cells [76]; endothelial cells [78, 83]; Langerhans cells following cell activation [84]. |
| MMP-24 (MT5-MMP) | Isolated from mouse brain cDNA library [54] | Predominantly expressed in the central nervous system [85] and in T lymphocytes [76]. |
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GPI-anchored MMPs | MMP-17 (MT4-MMP) | Isolated from a human breast carcinoma cDNA library [66] | Expressed in monocytic cells [86], leukocytes, brain, ovary, testis, and colon [66].MMP-17 mRNA is significantly represented in B cells [76]. |
| MMP-25 (MT6-MMP) | Isolated from peripheral blood leukocytes [64] | Predominantly expressed in leukocytes [64]. In rats, mRNA peak expression levels in testis, kidney, and skeletal muscle [85]. |
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| Type II transmembrane MMPs | MMP-23 | Isolated from an ovarian cDNA library [3] | Abundantly expressed in normal tissues in adults under quiescent conditions and predominantly expressed in reproductive tissues and others such as heart [3]. |
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