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Biochemistry Research International
Volume 2011, Article ID 238601, 8 pages
Review Article

Transcriptional Modulation of Heat-Shock Protein Gene Expression

Medical Molecular Biology Unit, Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK

Received 1 June 2010; Accepted 2 August 2010

Academic Editor: Daniel N. Hebert

Copyright © 2011 Anastasis Stephanou and David S. Latchman. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Heat-shock proteins (Hsps) are molecular chaperones that are ubiquitously expressed but are also induced in cells exposed to stressful stimuli. Hsps have been implicated in the induction and propagation of several diseases. This paper focuses on regulatory factors that control the transcription of the genes encoding Hsps. We also highlight how distinct transcription factors are able to interact and modulate Hsps in different pathological states. Thus, a better understanding of the complex signaling pathways regulating Hsp expression may lead to novel therapeutic targets.