Table of Contents Author Guidelines Submit a Manuscript
Biochemistry Research International
Volume 2011 (2011), Article ID 285618, 5 pages
Research Article

Effect of Plant Polyphenols on Adipokine Secretion from Human SGBS Adipocytes

1Laboratory of Physiology, School of Medicine, University of Ioannina, 45110 Ioannina, Greece
2Department of Internal Medicine, School of Medicine, University of Ioannina, 45110 Ioannina, Greece
3Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece

Received 19 April 2011; Revised 4 July 2011; Accepted 23 July 2011

Academic Editor: Tzi-Bunb Ng

Copyright © 2011 Christos S. Derdemezis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Adipose tissue contributes to atherosclerosis with mechanisms related to adipokine secretion. Polyphenols may exhibit antiatherogenic properties. The aim of the study was to investigate the effects of three polyphenols, namely, quercetin, epigallocatechin gallate (EGCG), and resveratrol on adipokine secretion from cultured human adipocytes. Methods. Human SGBS adipocytes were treated with quercetin, EGCG, and resveratrol for 24 and 48 hours. Visfatin, leptin, and adiponectin were measured in the supernatant. Results. Visfatin secretion was inhibited by quercetin 10 μM by 16% and 24% at 24 and 48 hours respectively. The corresponding changes for quercetin 25 μM were 47% and 48%. Resveratrol 25 μM reduced visfatin by 28% and 38% at 24 and 48 hours. EGCG did not have an effect on visfatin. None of tested polyphenols influenced leptin and adiponectin secretion. Conclusion. Quercetin and resveratrol significantly decreased visfatin secretion from SGBS adipocytes. This effect may contribute to their overall antiatherogenic properties.