Mechanism(s) of Toxic Action of Zn²⁺ and Selenite: A Study on AS-30D Hepatoma Cells and Isolated Mitochondria

Table 1

Action of cyclosporine A on AS-30D cell death produced by high concentrations of Zn²⁺ and selenite.

Treatment (24 h)	50 𝜇M Se	250 𝜇M Zn	500 𝜇M Zn
none	27±3	31±5	17±6
+ CsA (1 𝜇M)	41±1 *	55±5 **	30±6 **

The cell viability assayed by the trypan blue exclusion test is expressed in % to untreated control. Mean ±SE; 𝑛=4 independent experiments; *𝑃 < 0.05 compared to selenite-treated control; **𝑃 < 0.05 compared to Zn(II)-treated control.