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Biochemistry Research International
Volume 2011, Article ID 784698, 8 pages
http://dx.doi.org/10.1155/2011/784698
Research Article

Apple Procyanidins Suppress Amyloid -Protein Aggregation

1Molecular Gerontology, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakae-cho, Itabashi-ku, Tokyo 173-0015, Japan
2JAC Co., Ltd., 1-2-7 Higashiyama, Meguro-ku, Tokyo 153-0043, Japan
3Asahi Breweries, Ltd., 1-1-21 Midori, Moriya-shi, Ibaraki 302-0106, Japan
4Ageing Control Medicine, Juntendo University Graduate School of Medicine, 3-1-3-10-201 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Received 28 December 2010; Revised 11 May 2011; Accepted 27 May 2011

Academic Editor: Sanford I. Bernstein

Copyright © 2011 Toshihiko Toda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Procyanidins (PCs) are major components of the apple polyphenols (APs). We previously reported that treatment with PC extended the mean lifespan of Caenorhabditis elegans (Sunagawa et al., 2011). In order to estimate the neuroprotective effects of PC, we investigated the antiaggregative activity of PC on amyloid β-protein (Aβ) aggregation, which is a pathological hallmark of Alzheimer's disease. We herein report that PC significantly suppressed Aβ42 aggregation and dissociated Aβ42 aggregates in a dose-dependent manner, indicating that PC is a potent suppressor of Aβ aggregation. Furthermore, PC significantly inhibited Aβ42 neurotoxicity and stimulated proliferation in PC-12 cells. These results suggested that the PC and AP acted as neuroprotective factors against toxic Aβ aggregates.