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Biochemistry Research International
Volume 2011, Article ID 809259, 9 pages
http://dx.doi.org/10.1155/2011/809259
Review Article

Novel Insights into the Role of Caveolin-2 in Cell- and Tissue-Specific Signaling and Function

Department of Medical Pharmacology and Physiology, University of Missouri, Columbia, MO 65212, USA

Received 7 September 2011; Accepted 13 October 2011

Academic Editor: Andrei Surguchov

Copyright © 2011 Grzegorz Sowa. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Caveolin-2 is one of the major protein components of cholesterol- and glycosphingolipid-rich flask-shaped invaginations of plasma membrane caveolae. A new body of evidence suggests that caveolin-2 plays an important, and often more direct, role than caveolin-1 in regulating signaling and function in a cell- and tissue type-specific manner. The purpose of this paper is to primarily focus on discussing how these recent discoveries may help better understand the specific contribution of caveolin-2 to lipid raft- and caveolae-regulated cell/tissue-specific signaling and functions.