Ubiquitin C-Terminal Hydrolase L1 in Tumorigenesis

Table 1

Aberrant expression of UCH-L1 in tumor tissues and cancer cells.

Elevated UCH-L1	Down-Regulated UCH-L1
Malignant Tumors
Squamous cell carcinoma [31]	Prostate tumors [46]
Medullary thyroid carcinoma tumors [38]	Primary breast cancer tumors [16]
Osteosarcoma [45]	Primary nasopharyngeal carcinoma [10]
Adenocarcinoma [35]	Colorectal carcinoma [47]
Metastatic colorectal cancer tumors [9]	Melanoma [48]
Breast cancer tumors [37]	Diffuse-type gastric cancer [34]
Pancreatic ductal carcinoma tumors [36]
Parathyroid carcinoma [49]
Transformed Cells
SaOS-2 osteosarcoma cells [45]	LNCaP prostate cancer cells [50]
BLZ-211 and BLS-211 bladder cancer cells [43]
BL30, X-50/7, KR4, Raji, KR4 B-cell lymphoma cells [44]
HCT8 colorectal cancer cells [9]
DU154 prostate cancer cells [41, 42]
H157, W138, H358 lung carcinoma cells [8]