Implication of Mitochondrial Cytoprotection in Human Islet Isolation and Transplantation
Table 1
Oxygen carriers used in pancreas organ preservation and islet isolation.
Oxygen carriers
Benefits
Limitation
References
PFC
(i) Prevention of ischemia injury (ii) Improvement of islet yield and quality (iii) Inhibition of apoptosis by mitochondrial protection via oxygen loading (iv) Preservation of islet cell energetic status (v) Low islet oxidative stress (vi) Better in vivo islet graft function
(i) Inconsistent results despite several large-scale human trials (ii) May only be useful for marginal donors with prolonged ischemia (iii) Limited oxygen penetration into pancreas (iv) Poor water solubility (v) Indeterminate biosafety
(i) Improvement of islet yield and quality (ii) Preservation of mitochondrial integrity (iii) No increase in oxidative stress (iv) Better in vivo islet graft function (v) High oxygen tension with oxygen saturation curve similar to RBCs
(i) Only in rodent model (ii) Warm-ischemia model used may not be applicable in a cold-ischemia model (iii) Product discontinued