Combination Effects of Docetaxel and Doxorubicin in Hormone-Refractory Prostate Cancer Cells

Table 1

Cytotoxicity of docetaxel (DOC) and doxorubicin (DOX) in hormone-refractory PC3 and DU145 cancer cell lines^a. IC50 values are given as mean.

	PC3			DU145
	IC50^b	EC50 (1)^c	EC50 (2)^c	IC50^b	EC50 (1)^c	EC50 (2)^c
DOC (nM)	0.598	0.500^d	92,000^d	0.469	0.392	104,000^d
DOX (nM)	908	N.D.	N.D.	343	N.D.	N.D.

^aCells were treated with either DOC or DOX alone.
^bIC50 denotes the half maximal inhibitory concentration.
^cEC50 (1) and EC50 (2) indicate the half effective concentrations in the first (1) and second (2) phase of the biphasic curve used to fit the cell viability data.
^dApproximate estimation due to insufficient data points.
N.D: Not determined.