No-Reflow Phenomenon and Endothelial Glycocalyx of Microcirculation

Figure 2

Schematic representation of the glycocalyx meshwork associated with cytoskeleton. Hyaluronan weaves into glycocalyx and binds with hyaladherins (CD-44 (hyalreceptor), RHAMM (receptor for hyaluronan-mediated motility), other proteins, or hyaluronansynthases). Chondroitin sulfate proteoglycan (versican) interacts with hyaluronan to form high molecular mass stable aggregates. Enhanced formation of hyaluronan-versican pericellular coat is observed under pathophysiological conditions (inflammation, early atherosclerosis, restenosis, plaque thrombosis, and others).