Role of in Replicative Senescence and DNA Damage-Induced Premature Senescence in p53-Deficient Human Cells
Figure 1
Multiple functions of the p16 tumor suppressor. This protein inhibits the kinase activities of CDK4 and CDK6 that mediate pRB phosphorylation [28–30], promotes MDM2-dependent degradation of p53 [40], downregulates AKT/survivin signaling [41], and represses the transcription of several genes including RB [39], TP53 [40], VEGF (vascular endothelial growth factor) [13], MMP-2 (matrix metalloproteinase 2) [32], and NF-κB [38].
