In Search of Novel Targets for Heart Disease: Myocardin and Myocardin-Related Transcriptional Cofactors

Figure 1

The myocardin family of transcriptional cofactors: protein signatures, domains, and functional sites. The domain/motif structures of the human proteins are shown: RPEL 1-3 (RPEL domain), B: basic domain, Q: glutamine-rich region, SAP: SAP domain; S: serine-rich region; CC: coiled-coil (leucine zipper-like) motif; P: proline-rich region; TAD: transcription activation domain. The regions essential for binding of transcription factors (TF). MEF2: myocyte enhancer factor-2 [32], TBX5: T-box transcription factor 5 [33], FOXO4: forkhead box protein O4 [34], GATA-4: member of GATA family of zinc finger transcription factors [35], NKX-3.1: homeobox NK-3 transcription factor-1 [36]. NT/CT: amino/carboxyl terminus.