Collagen Content in Skin and Internal Organs of the Tight Skin Mouse: An Animal Model of Scleroderma
Histopathology of tissues from wild type +/+ and mutant Tsk/+ mice. The genotype and gender of the mice are shown at the top. The tissue is shown at the left of the figure. Skin, lung, heart, and kidney samples from mice were removed, fixed, paraffin-embedded, sectioned, and stained with Masson’s trichrome. Collagen staining appears in blue. Compare the thickness of the collagen-containing dermal layer and the hypodermal or superficial fascia layer (shown in red brackets) beneath the panniculus carnosus in the skin. The age of the mice ranged between 23 and 27 weeks. Magnification is 200x.