Biochemistry Research International / 2013 / Article / Tab 3

Research Article

Collagen Content in Skin and Internal Organs of the Tight Skin Mouse: An Animal Model of Scleroderma

Table 3

Summary of published data showing skin thickness and hydroxyproline content in Tsk/+ and control mice.

Strain background GenotypeNo. of mice studiedAgeGenderDermal thickness (mm)Fold change in dermal thicknessbFold change in collagen or hydroxyproline contentbReference

B10.D2(58N)/SnNormal 56 monthsNGa Jimenez et al., 1984 [6]
B10.D2(58N)/SnTsk 56 monthsNG 2.02.5

NZBpa/+ 2NGNG Bocchieri et al., 1993 [19]
NZBTsk/+ 2NGNG2.3

C57BL/6pa/pa 52-3 monthsNG~0.180 Ong et al., 1999 [15]
BALB/c, C57BL/6Tsk/+ IL4+/+, STAT6+/+ 52-3 monthsNG~0.380 2.1
BALB/c, C57BL/6Tsk/+ IL4−/−, STAT6+/+ 52-3 monthsNG~0.190 1.0
BALB/c, C57BL/6Tsk/+ IL4+/−, STAT6+/+ 52-3 monthsNG~0.2901.6
BALB/c, C57BL/6Tsk/+ IL4+/+, STAT6+/− 52-3 monthsNG~0.1600.8
BALB/c, C57BL/6Tsk/+ IL4+/+, STAT6−/− 52-3 monthsNG~0.1700.9

C57BL/6pa/pa 6NGNG McGaha et al., 2001 [20]
C57BL/6 Tsk/+ pa/+ 13NGNG 1.72.0
BALB/c, C57BL/6Tsk/+, Il4Rα+/− 9NGNG 1.81.5
BALB/c, C57BL/6Tsk/+, Il4Rα−/− 9NGNG 1.00.9
C57BL/6 Tsk/+, Tgfb+/− 16NGNG 1.20.8
C57BL/6+/+, Tgfb+/− 3NGNG 0.90.8

C57BL/6 pa/pa 63 monthsNG Kodera et al., 2002 [16]
C57BL/6 Tsk/+ pa/+ 133 monthsNG 1.9
BALB/c, C57BL/6Tsk/+, Il4+/+ 63 monthsNG 2.7
BALB/c, C57BL/6Tsk/+, Il4+/− 123 monthsNG 1.7
BALB/c, C57BL/6Tsk/+, Il4−/− 273 monthsNG 1.2
BALB/c, C57BL/6Tsk/Tsk, Il4+/− 53 monthsNG 1.4
BALB/c, C57BL/6Tsk/Tsk, Il4−/− 53 monthsNG 1.2

C57BL/6+/+ NG3 monthsFemale~0.160 Saito et al., 2002 [21]
C57BL/6Tsk/+ NG3 monthsFemale~0.3901.11.25
C57BL/6, 129CD19 −/− NG3 monthsFemale~0.1601.01.0
C57BL/6, 129Tsk/+, CD19 −/− NG3 monthsFemale~0.3201.01.1

C57BL/6+/+ 11NG Del Prete et al., 2004 [22]
C57BL/6Tsk/+ 8NG

C57BL/6+/+ 236 weeksMale~0.8 Baxter et al., 2005 [23]
C57BL/6Tsk/+ pa/+ 346 weeksMale~1.52.0

NG: not given. bFold change is shown compared to control.