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Biochemistry Research International
Volume 2013 (2013), Article ID 506731, 8 pages
http://dx.doi.org/10.1155/2013/506731
Research Article

miR-149 Inhibits Non-Small-Cell Lung Cancer Cells EMT by Targeting FOXM1

1Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
2Department of Oncology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China

Received 4 March 2013; Revised 19 April 2013; Accepted 19 April 2013

Academic Editor: Vladimir Uversky

Copyright © 2013 Yang Ke et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

MicroRNAs (miRNAs) have been implied to play crucial roles for epithelial-to-mesenchymal transition (EMT) of non-small-cell lung cancer cells (NSCLC cells). Here we found that the expression of miR-149, downregulated in lung cancer, was inversely correlated with invasive capability and the EMT phenotype of NSCLC cells. miR-149 inhibited EMT in NSCLC cells. Furthermore, we demonstrated that miR-149 directly targeted Forkhead box M1 (FOXM1), and FOXM1 was involved in the EMT induced by TGF-β1 in A549 cells. Overexpression of FOXM1 restored EMT process inhibited by miR-149. Our work suggested that miR-149 might be an EMT suppressor in NSCLC cells.