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Biochemistry Research International
Volume 2013, Article ID 527205, 6 pages
http://dx.doi.org/10.1155/2013/527205
Research Article

Evaluation of Mallotus oppositifolius Methanol Leaf Extract on the Glycaemia and Lipid Peroxidation in Alloxan-Induced Diabetic Rats: A Preliminary Study

1Department of Biochemistry, Faculty of Basic Medical Sciences, University of Calabar, Calabar, Cross River State, Nigeria
2Department of Veterinary Physiology and Pharmacology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Enugu State, Nigeria
3Department of Veterinary Physiology, Biochemistry and Pharmacology, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Abia State, Nigeria
4The Royal Veterinary College, University of London, London, UK
5Department of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Abuja, Abuja, Nigeria

Received 12 July 2013; Revised 5 September 2013; Accepted 14 September 2013

Academic Editor: Gary S. Shaw

Copyright © 2013 C. O. Nwaehujor et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. K. Vinuthan, G. Kumara, M. Narayanaswamya, and T. Veena, “Lipid lowering effect of aqueous leaves extract of Murraya koenigii (curry leaf) on alloxan-induced male diabetic rats,” Pharmacognosy Magazine, vol. 3, pp. 112–115, 2007. View at Google Scholar
  2. I. I. Ezeigbo, “Antidiabetic potential of methanolic leaf extracts of Icacina trichantha in alloxan-induced diabetic mice,” International Journal of Diabetes in Developing Countries, vol. 30, no. 3, pp. 150–152, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. R. V. Jayakumar, “Herbal medicines for type-2 diabetes,” International Journal of Diabetes in Developing Countries, vol. 30, no. 3, pp. 111–112, 2010. View at Publisher · View at Google Scholar · View at Scopus
  4. M. R. Taskinen, “Lipoprotein lipase in diabetes,” Diabetes/Metabolism Reviews, vol. 3, no. 2, pp. 551–570, 1987. View at Google Scholar · View at Scopus
  5. A. Scoppola, F. R. Montecchi, G. Menzinger, and A. Lala, “Urinary mevalonate excretion rate in type 2 diabetes: role of metabolic control,” Atherosclerosis, vol. 156, no. 2, pp. 357–361, 2001. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Uchimura, A. Nagasaka, R. Hayashi et al., “Changes in superoxide dismutase activities and concentrations and myeloperoxidase activities in leukocytes from patients with diabetes mellitus,” Journal of Diabetes and Its Complications, vol. 13, no. 5-6, pp. 264–270, 1999. View at Publisher · View at Google Scholar · View at Scopus
  7. N. H. Ugochukwu, N. E. Babady, M. Cobourne, and S. R. Gasset, “The effect of Gongronema latifolium extracts on serum lipid profile and oxidative stress in hepatocytes of diabetic rats,” Journal of Biosciences, vol. 28, no. 1, pp. 1–5, 2003. View at Google Scholar · View at Scopus
  8. F. A. Kabran, A. Maciuk, T. A. Okpekon et al., “Phytochemical and biological analysis of M. oppositifolius (Euphorbiaceae),” Planta Medica, vol. 78, no. 11, p. 1381, 2012. View at Publisher · View at Google Scholar
  9. E. O. Farombi, O. O. Ogundipe, and J. O. Moody, “Antioxidant and anti-inflammatory activities of Mallotus oppositifolium in model systems,” African Journal of Medicine and Medical Sciences, vol. 30, no. 3, pp. 213–215, 2001. View at Google Scholar · View at Scopus
  10. M. M. Iwu, Handbook of African Medicinal Plants, CRC Press, Boca Raton, Fla, USA, 1993.
  11. M. U. Anthony and A. O. Adebimpe, “Hypoglycemic potential of the young leave methanolic extract of Mangifera indica in alloxan induced diabetic rat,” Pakistan Journal of Nutrition, vol. 8, no. 3, pp. 239–241, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. I. I. Ezeigbo, “The antidiabetic potentials of the methanolic seed extract of Buchhlozia coriacea,” Annals of Medical and Health Sciences Research, vol. 1, no. 2, pp. 159–163, 2011. View at Google Scholar
  13. N. Malviya, S. Jain, and S. Malviya, “Antidiabetic potential of medicinal plants,” Acta Poloniae Pharmaceutica—Drug Research, vol. 67, no. 2, pp. 113–118, 2010. View at Google Scholar · View at Scopus
  14. F. W. Sunderman Jr., A. Marzouk, S. M. Hopfer, S. M. Hopfer, O. Zaharia, and M. C. Reid, “Increased lipid peroxidation in tissues of nickel chloride-treated rats,” Annals of Clinical and Laboratory Science, vol. 15, no. 3, pp. 229–236, 1985. View at Google Scholar · View at Scopus
  15. C. C. Allain, L. S. Poon, and C. S. G. Chan, “Enzymatic determination of total serum cholesterol,” Clinical Chemistry, vol. 20, no. 4, pp. 470–475, 1974. View at Google Scholar · View at Scopus
  16. F. F. Benzie and J. J. Strain, “Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration,” Methods in Enzymology, vol. 299, pp. 15–27, 1998. View at Publisher · View at Google Scholar · View at Scopus
  17. L. L. Mensor, F. S. Menezes, G. G. Leitão et al., “Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method,” Phytotherapy Research, vol. 15, no. 2, pp. 127–130, 2001. View at Publisher · View at Google Scholar
  18. G. H. Schmelzer, E. G. Achigan-Dako, and C. H. Bosch, Medicinal Plants of Tropical Africa, PROTA Foundation, Nairobi, Kenya, 2010.
  19. S. P. Wolff, Z. Y. Jiang, and J. V. Hunt, “Protein glycation and oxidative stress in diabetes mellitus and ageing,” Free Radical Biology and Medicine, vol. 10, no. 5, pp. 339–352, 1991. View at Publisher · View at Google Scholar · View at Scopus
  20. R. N. Okigbo, C. L. Anuagasi, and J. E. Amadi, “Advances in selected medicinal and aromatic plants indigenous to Africa,” Journal of Medicinal Plant Research, vol. 3, no. 2, pp. 86–95, 2009. View at Google Scholar · View at Scopus
  21. E. Middleton Jr., C. Kandaswami, and T. C. Theoharides, “The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer,” Pharmacological Reviews, vol. 52, no. 4, pp. 673–751, 2000. View at Google Scholar · View at Scopus
  22. D. E. Gutstein and V. Fuster, “Pathophysiology and clinical significance of atherosclerotic plaque rupture,” Cardiovascular Research, vol. 41, no. 2, pp. 323–333, 1999. View at Publisher · View at Google Scholar · View at Scopus
  23. M. O. Sofidiya, O. A. Odukoya, O. B. Familoni, and S. I. Inya-Agha, “Free radical scavenging activity of some Nigerian medicinal plant extracts,” Pakistan Journal of Biological Sciences, vol. 9, no. 8, pp. 1438–1441, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Hodek, P. Trefil, and M. Stiborová, “Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450,” Chemico-Biological Interactions, vol. 139, no. 1, pp. 1–21, 2002. View at Publisher · View at Google Scholar · View at Scopus
  25. M. B. Krawinkel and G. B. Keding, “Bitter gourd (Momordica charantia): a dietary approach to hyperglycemia,” Nutrition Reviews, vol. 64, no. 7, pp. 331–337, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. J. K. Grover, S. Yadav, and V. Vats, “Medicinal plants of India with anti-diabetic potential,” Journal of Ethnopharmacology, vol. 81, no. 1, pp. 81–100, 2002. View at Publisher · View at Google Scholar · View at Scopus
  27. K. Azad, J. M. Parkin, S. Court, M. F. Laker, and K. G. M. M. Alberti, “Circulating lipids and glycaemic control in insulin dependent diabetic children,” Archives of Disease in Childhood, vol. 71, no. 2, pp. 108–113, 1994. View at Google Scholar · View at Scopus
  28. V. A. Diwadkar, J. W. Anderson, S. R. Bridges, M. S. Gowri, and P. R. Oelgten, “Postprandial low-density lipoproteins in type 2 diabetes are oxidized more extensively than fasting diabetes and control samples,” Proceedings of the Society for Experimental Biology and Medicine, vol. 222, no. 2, pp. 178–184, 1999. View at Google Scholar · View at Scopus
  29. B. Rodrigues and J. H. McNeil, “Cardiac function in spontaneously hypertensive diabetic rats,” The American Journal of Physiology—Heart and Circulatory Physiology, vol. 251, no. 3, part 2, pp. H571–H580, 1986. View at Google Scholar
  30. J. J. Genest, J. R. McNamara, D. N. Salem, and E. J. Schaefer, “Prevalence of risk factors in men with premature coronary artery disease,” The American Journal of Cardiology, vol. 67, no. 15, pp. 1185–1189, 1991. View at Publisher · View at Google Scholar · View at Scopus
  31. M. D. Sharma, J. A. Farmer, and A. Garber, “Type 2 diabetes and cardiovascular risk factors,” Current Medical Research and Opinion, vol. 27, supplement 3, pp. 1–5, 2011. View at Google Scholar
  32. G. N. Levine, J. F. Keaney Jr., and J. A. Vita, “Cholesterol reduction in cardiovascular disease—clinical benefits and possible mechanisms,” The New England Journal of Medicine, vol. 332, no. 8, pp. 512–521, 1995. View at Publisher · View at Google Scholar · View at Scopus