Penetration of Milk-Derived Antimicrobial Peptides into Phospholipid Monolayers as Model Biomembranes

Figure 1

Compression isotherms of surface pressure, Π versus 𝐴, (curves 1 and 2) and electric surface potential, Δ𝑉 versus 𝐴 (curves 1′ and 2′) of: (a) DPPC and (b) DPPG monolayers spread on subphase of water (curves 1 and 1′) and lactophoricin (N-23-T) solution, 1 μM (curves 2 and 2′); “𝐴” denotes area per the phospholipid molecule. The inserts show the surface compression modulus (𝐶_𝑠⁻¹) calculated according to (1) as a function of Π of the pure lipid monolayer (solid lines) and that spread on lactophoricin solution (dotted lines).

(a)

(b)