Improved Rifamycin B Production by Nocardia mediterranei MTCC 14 under Solid-State Fermentation through Process Optimization

Table 6

ANOVA for the fitted quadratic polynomial model of rifamycin B production from mediterranei MTCC 14 by using central composite design.

Source	SS	DF	MS	value	value	Significance
Model	453.92	14	32.42	22.59	<0.0001	Significant
	66.40	1	66.40	46.27	<0.0001	Significant
	1.29	1	1.29	0.90	0.3584	Not significant
	3.82	1	3.82	2.66	0.1234	Not significant
	45.49	1	45.49	31.70	<0.0001	Significant
	39.25	1	39.25	27.35	0.0001	Significant
	2.25	1	2.25	1.57	0.2297	Not significant
	0.37	1	0.37	0.26	0.6209	Not significant
	4.45	1	4.45	3.10	0.0985	Not significant
	101.51	1	101.51	70.74	<0.0001	Significant
	0.24	1	0.24	0.17	0.6833	Not significant
	33.60	1	33.60	23.42	0.0002	Significant
	141.26	1	141.26	98.44	<0.0001	Significant
	1.38	1	1.38	0.96	0.3422	Not significant
	54.48	1	54.48	37.97	<0.0001	Significant
Residual	21.52	15	1.43
Lack of fit	21.25	10	2.12	38.55	0.0004	Not significant
Pure error	0.28	5	0.055
Cor. total	475.45	29
Std. dev.: 1.20, : 0.9547.; Mean: 4.55, adjusted : 0.9125.; Coefficient of variation (CV) %: 26.34, predicted : 0.7118.; Predicted residual sum of squares (PRESS): 122.79, adequate precision: 12.510.

SS: sum of square, MS: mean of square, and df: degree of freedom.