Table of Contents Author Guidelines Submit a Manuscript
Biochemistry Research International
Volume 2014, Article ID 657189, 12 pages
http://dx.doi.org/10.1155/2014/657189
Review Article

Exploring Drug Targets in Isoprenoid Biosynthetic Pathway for Plasmodium falciparum

1Department of Biotechnology, Faculty of Engineering & Technology, Raja Balwant Singh, Engineering Technical Campus, Agra 283105, India
2Department of Biochemistry, Dr. Ram Manohar Lohia Avadh University, Faizabad 224001, India
3Department of Biotechnology, Babasaheb Bhimrao Ambedkar University, Lucknow, India
4Department of Biochemistry, University of Allahabad, Allahabad, India

Received 24 December 2013; Revised 7 February 2014; Accepted 7 February 2014; Published 23 April 2014

Academic Editor: Andrei Surguchov

Copyright © 2014 Tabish Qidwai et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Emergence of rapid drug resistance to existing antimalarial drugs in Plasmodium falciparum has created the need for prediction of novel targets as well as leads derived from original molecules with improved activity against a validated drug target. The malaria parasite has a plant plastid-like apicoplast. To overcome the problem of falciparum malaria, the metabolic pathways in parasite apicoplast have been used as antimalarial drug targets. Among several pathways in apicoplast, isoprenoid biosynthesis is one of the important pathways for parasite as its multiplication in human erythrocytes requires isoprenoids. Therefore targeting this pathway and exploring leads with improved activity is a highly attractive approach. This report has explored progress towards the study of proteins and inhibitors of isoprenoid biosynthesis pathway. For more comprehensive analysis, antimalarial drug-protein interaction has been covered.