Cytotoxic Effects of Newly Synthesized Palladium(II) Complexes of Diethyldithiocarbamate on Gastrointestinal Cancer Cell Lines
Table 2
The Pd(II) induced cell cycle arrest. The cell cycle progression blockage was seen in G2-M after 24 hrs of treatment with the IC50 of the Pd(II) complexes.
AGS
Kyse-30
HepG2
G0-G1%
S%
G2M%
G0-G1%
S%
G2M%
G0-G1%
S%
G2M%
Control
53.85 ± 1.95
21.27 ± 3.50
24.88 ± 2.20
54.39 ± 1.32
16.6 ± 1.59
29.01 ± 1.83
55.97 ± 0.4795
16.35 ± 0.99
27.68 ± 1.86
Complex 1
50 ± 1.44
12.15 ± 0.59
37.84 ± 1.66a
53.01 ± 3.48
23.92 ± 0.26a
22.4 ± 3.16
52.04 ± 3.06
11.39 ± 4.84
36.57 ± 2.76a
Complex 2
51.24 ± 4.65
9.29 ± 0.56
39.47 ± 4.1a
49.98 ± 1.68
21.31 ± 2.13a
28.70 ± 4.98
47.41 ± 4.2
16.68 ± 1.53
35.90 ± 0.97a
Complex 3
52.85 ± 3.77
11.83 ± 6.95
35.31 ± 4.16a
47.96 ± 7.65
25.17 ± 3.52a
26.87 ± 4.13
46.64 ± 4.64
14.19 ± 2.20
39.18 ± 3.15a
The data were pooled from three independent tests and were presented as mean ± STDEV; a<0.05.