A Polymorphism in Hepatocyte Nuclear Factor 1 Alpha, rs7310409, Is Associated with Left Main Coronary Artery Disease
Table 3
Main effects of SNPs on LMCAD risk.
Genotyped SNP
Genotyping (AA/AB/BB)a
AB versus AA adjusted OR (95% CI); value
BB versus AA adjusted OR (95% CI); value
BB versus (AA + AB) adjusted OR (95% CI); value
(BB + AB) versus AA adjusted OR (95% CI); value
-trend
LMCAD ()
MPCAD ()
HNF1A: rs7310409 G/A
110/201/90
282/361/160
1.46 (1.10–1.93); 0.009
1.45 (1.03–2.04); 0.033
1.16 (0.86–1.55); 0.331
1.45 (1.17–1.89); 0.006
0.027
CRP: rs1800947 G/C
367/34/0
745/58/1
1.20 (0.77–1.87); 0.417
—; 0.981
—; 0.981
1.18 (0.76–1.84); 0.458
0.578
CRP: rs3093059 T/C
282/102/17
552/231/20
0.88 (0.67–1.16); 0.365
1.68 (0.86–3.28); 0.127
1.74 (0.90–3.38); 0.100
0.95 (0.73–1.23); 0.671
0.147
MTHFR: rs1801133 T/C
133/199/69
291/372/140
1.15 (0.88–1.51); 0.298
1.07 (0.75–1.52); 0.725
0.98 (0.71–1.35); 0.905
1.13 (0.88–1.46); 0.347
0.512
MTHFD: rs1076991 A/G
217/151/33
434/302/67
0.98 (0.76–1.27); 0.876
0.97 (0.62–1.52); 0.887
0.98 (0.63–1.51); 0.914
0.98 (0.77–1.25); 0.855
0.998
aAA/AB/BB are dominant homozygote, heterozygote, and recessive homozygote, respectively; bold values are statistically significant (); Bonferroni correction was performed to correct the value (); for HNF1A rs7310409 G/A, = 0.045 for GA versus GG, = 0.165 for AA versus GG, = 1.000 for AA versus GG/GA, and = 0.030 for GA/AA versus GG after being adjusted for age and sex. For the rest of the 4 SNPs, > 0.05 in all comparison models, adjusted for age and sex.
