Modulation of Adipocytokines Production and Serum NEFA Level by Metformin, Glimepiride, and Sitagliptin in HFD/STZ Diabetic Rats

Table 1

Change in body weight of different studied groups during the treatment period (4 weeks).

Weeks	Control	Diabetic
		Untreated	Metformin	Glimepiride	Sitagliptin
After induction of T2DM (before starting treatments)	113.9 ± 13.9	132.2 ± 21^a	131.2 ± 13.9^a	130.6 ± 16.5^a	133.3 ± 11.2^a
Week ()	127.8 ± 18.9	134.3 ± 23	140.4 ± 12	137 ± 13.4	135.7 ± 14.1
Week ()	129.9 ± 17.1	145.2 ± 21.2^a	139.1 ± 8.6	139.9 ± 17.2	140.3 ± 15.1
Week ()	139.2 ± 19.7	149.1 ± 23.1	141.3 ± 11.7	150.9 ± 22.5	155.4 ± 15.5
Week ()	146.1 ± 18.3	151.6 ± 25.8	142.9 ± 10.1	154.8 ± 21.5	160.6 ± 17.5^c

Values are presented as mean ± SD (). Significantly different from the control group and significantly different from the Metformin group, using ANOVA (LSD), value < 0.05.