Modulation of Adipocytokines Production and Serum NEFA Level by Metformin, Glimepiride, and Sitagliptin in HFD/STZ Diabetic Rats

Table 2

Baseline values of glucose homeostasis parameters and lipid profile of different studied groups.

Parameter	Control	Diabetic
		Untreated	Metformin	Glimepiride	Sitagliptin
Fasting blood glucose (mg/dL)	88 ± 7.1	361.8 ± 43.9^a	354.2 ± 47^a	355.7 ± 63.1^a	362.9 ± 52.6^a
Serum insulin (IU/mL)	1.7 ± 0.2	11.1 ± 0.4^a	10.9 ± 0.4^a	11.1 ± 0.5^a	11.2 ± 0.3^a
HOMA-IR	0.42 ± 0.1	7.6 ± 1.1^a	7.8 ± 1.3^a	7.5 ± 1.2^a	7.6 ± 1.2^a
Triglycerides (mg/dL)	42.3 ± 3.8	111.8 ± 13.2^a	113.6 ± 14.8^a	112.1 ± 12.4^a	113.1 ± 12.9^a
Total cholesterol (mg/dL)	142.3 ± 6.7	179.8 ± 12.1^a	178.1 ± 11.8^a	180.1 ± 12.6^a	179.4 ± 11.7^a
LDL-cholesterol (mg/dL)	89.4 ± 12.8	121.8 ± 14.7^a	122.3 ± 12.9^a	122.5 ± 13.4^a	121.2 ± 13.1^a
HDL-cholesterol (mg/dL)	41.2 ± 0.9	37.1 ± 1.9^a	37.4 ± 2.1^a	36.9 ± 2.2^a	37.2 ± 1.8^a

Values are presented as mean ± SD (). ^aSignificantly different from the control group by ANOVA (LSD), value < 0.05.