Similar and Additive Effects of Ovariectomy and Diabetes on Insulin Resistance and Lipid Metabolism

Table 1

Parameters of glucose homeostasis, lipid profile, and hepatic lipid content of different studied groups at the end of the study.

Parameter	Sham control	OVX control	Diabetic	OVX diabetic
Fasting blood glucose (mg/dl)	86.9 ± 11.8	104.1 ± 5.9^a	159.7 ± 8.3^a,b	174.4 ± 30.7^a,b
Serum insulin (IU/ml)	4.8 ± 1.8	13.4 ± 1.1^a	22.1 ± 1.0^a,b	29.3 ± 1.5^a,b,c
HOMA-IR	0.96 ± 0.3	3.45 ± 0.3^a	8.67 ± 0.5^a,b	12.6 ± 2.2^a,b,c
Triglycerides (mg/dl)	89.9 ± 9.8	115.2 ± 5.4^a	126.8 ± 4.73^a	142.8 ± 26.2^a,b,c
Total cholesterol (mg/dl)	143.6 ± 21.3	194.5 ± 6.5^a	213.5 ± 3.6^a,b	241.4 ± 4.8^a,b,c
LDL cholesterol (mg/dl)	75.5 ± 17.7	127.9 ± 6.4^a	150.4 ± 4.6^a,b	181.6 ± 9.4^a,b,c
HDL cholesterol (mg/dl)	49.9 ± 6.3	43.5 ± 1.87^a	37.8 ± 2.1^a,b	31.1 ± 2.7^a,b,c
Serum NEFA (mmol/dl)	5.7 ± 1.4	12.2 ± 1.1^a	32.2 ± 1.5^a,b	39.5 ± 2.1^a,b,c
Hepatic triglycerides content (mg/g liver)	102.4 ± 8.5	110.6 ± 7.4^a	130.1 ± 6.7^a,b	163.7 ± 9.3^a,b,c
Hepatic cholesterol content (mg/g liver)	40.9 ± 4.1	46.5 ± 2.2^a	46.4 ± 3.1^a	48.2 ± 4.9^a

Values are presented as mean ± SD ( = 10). Sham: sham-operated rats, OVX: ovariectomized rats. ^aSignificantly different from the sham control group, ^bsignificantly different from the OVX control group, and ^csignificantly different from the diabetic group, using ANOVA (LSD), value < 0.05.