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Biochemistry Research International
Volume 2015, Article ID 617620, 9 pages
http://dx.doi.org/10.1155/2015/617620
Research Article

Modulatory Effects of Eschscholzia californica Alkaloids on Recombinant GABAA Receptors

1Michelin Recherche et Technique S.A., Route André-Piller 30, 1762 Givisiez, Switzerland
2Department of Biochemistry, Faculty of Medicine, Masaryk University, 62500 Brno, Czech Republic
3Institute of Biochemistry and Molecular Medicine, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland

Received 28 July 2015; Revised 5 September 2015; Accepted 15 September 2015

Academic Editor: Emanuel Strehler

Copyright © 2015 Milan Fedurco et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Figure S1. ESI trace (a) and tandem MS/MS fragmentation pattern (b-c) for (S)-Reticuline detected in the “NMT fraction” isolated from E. californica (see the main text).

Figure S2. ESI trace (a) and tandem MS/MS fragmentation pattern (b) for Californidine isolated from E. californica, Arcopharma, no. AMM 57426001 (Method A).

Figure S3. ESI trace (a) and tandem MS/MS fragmentation pattern (b) for Eschscholtzine isolated from E. californica, Arcopharma, no. AMM 57426001 (Method A).

Figure S4. ESI trace (a) and tandem MS/MS fragmentation pattern (b) for O-methylcaryachine isolated from E. californica, Arcopharma, no. AMM 57426001 (Method A).

Figure S5. ESI trace (a) and tandem MS/MS fragmentation pattern (b) for α-allocryptopine isolated from E. californica, Arcopharma, no. AMM 57426001 (Method A).

Figure S6. ESI trace (a) and tandem MS/MS fragmentation pattern (b) for N-methyllaurotetanine isolated from E. californica, Arcopharma, no. AMM 57426001 (Method A).

Figure S7. ESI trace (a) and MS/MS fragmentation pattern (b) for the commercial Protopine sample obtained from Sigma (product number: P8489).

Figure S8. ESI trace (a) and MS/MS fragmentation pattern (b) for the commercial α-allocryptopine obtained from Aldrich (product number: S450987).

  1. Supplementary Material