Transcriptional Activation of p53 during Cold Induced Torpor in the 13-Lined Ground Squirrel Ictidomys tridecemlineatus

Figure 4

Transcriptional regulation of p53 in the hibernation cycle. Transcript levels of (a) p53, mdm2, and (b) p53 downstream targets 14-3-3σ, p21, and gadd-45α are shown in the ground squirrel skeletal muscle over six stages of the hibernation cycle. Transcript levels were normalized to the housekeeping gene α-tubulin. Data show means ± SEM, -5 independent trials on tissues from different animals. denotes significant statistical difference from EC values, .

(a)

(b)