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Biochemistry Research International
Volume 2015 (2015), Article ID 731595, 11 pages
http://dx.doi.org/10.1155/2015/731595
Research Article

Transcriptional Activation of p53 during Cold Induced Torpor in the 13-Lined Ground Squirrel Ictidomys tridecemlineatus

Institute of Biochemistry and Department of Biology, Carleton University, 1125 Colonel By Drive, Ottawa, ON, Canada K1S 5B6

Received 28 October 2015; Accepted 14 December 2015

Academic Editor: Emanuel Strehler

Copyright © 2015 Joshua Hefler et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. V. Carey, M. T. Andrews, and S. L. Martin, “Mammalian hibernation: cellular and molecular responses to depressed metabolism and low temperature,” Physiological Reviews, vol. 83, no. 4, pp. 1153–1181, 2003. View at Publisher · View at Google Scholar · View at Scopus
  2. P. Morin Jr. and K. B. Storey, “Evidence for a reduced transcriptional state during hibernation in ground squirrels,” Cryobiology, vol. 53, no. 3, pp. 310–318, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. K. U. Frerichs, C. B. Smith, M. Brenner et al., “Suppression of protein synthesis in brain during hibernation involves inhibition of protein initiation and elongation,” Proceedings of the National Academy of Sciences of the United States of America, vol. 95, no. 24, pp. 14511–14516, 1998. View at Publisher · View at Google Scholar · View at Scopus
  4. T. Ruf and F. Geiser, “Daily torpor and hibernation in birds and mammals,” Biological Reviews, vol. 90, no. 3, pp. 891–926, 2015. View at Publisher · View at Google Scholar
  5. K. B. Storey, “Out cold: biochemical regulation of mammalian hibernation—a mini-review,” Gerontology, vol. 56, no. 2, pp. 220–230, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. A. J. Levine, W. Hu, and Z. Feng, “The P53 pathway: what questions remain to be explored?” Cell Death & Differentiation, vol. 13, no. 6, pp. 1027–1036, 2006. View at Publisher · View at Google Scholar · View at Scopus
  7. C. A. Brady and L. D. Attardi, “p53 at a glance,” Journal of Cell Science, vol. 123, no. 15, pp. 2527–2532, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Hermeking and A. Benzinger, “14-3-3 Proteins in cell cycle regulation,” Seminars in Cancer Biology, vol. 16, no. 3, pp. 183–192, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. W. R. Taylor and G. R. Stark, “Regulation of the G2/M transition by p53,” Oncogene, vol. 20, no. 15, pp. 1803–1815, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. U. M. Moll and O. Petrenko, “The MDM2-p53 Interaction,” Molecular Cancer Research, vol. 1, no. 14, pp. 1001–1008, 2003. View at Google Scholar · View at Scopus
  11. D. C. McMullen and J. M. Hallenbeck, “Regulation of Akt during torpor in the hibernating ground squirrel, Ictidomys tridecemlineatus,” Journal of Comparative Physiology B, vol. 180, no. 6, pp. 927–934, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. C. W. Wu, R. A. Bell, and K. B. Storey, “Post-translational regulation of PTEN catalytic function and protein stability in the hibernating 13-lined ground squirrel,” Biochimica et Biophysica Acta, vol. 1850, pp. 2196–2202, 2015. View at Publisher · View at Google Scholar
  13. C.-W. Wu and K. B. Storey, “Regulation of the mTOR signaling network in hibernating thirteen-lined ground squirrels,” Journal of Experimental Biology, vol. 215, no. 10, pp. 1720–1727, 2012. View at Publisher · View at Google Scholar · View at Scopus
  14. J. D. Dignani, R. M. Lebovitz, and R. G. Roeder, “Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei,” Nucleic Acids Research, vol. 11, no. 5, pp. 1475–1489, 1983. View at Publisher · View at Google Scholar · View at Scopus
  15. C. Dai and W. Gu, “p53 Post-translational modification: deregulated in tumorigenesis,” Trends in Molecular Medicine, vol. 16, no. 11, pp. 528–536, 2010. View at Publisher · View at Google Scholar · View at Scopus
  16. N. J. Maclaine and T. R. Hupp, “The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway,” Aging, vol. 1, no. 5, pp. 490–502, 2009. View at Google Scholar · View at Scopus
  17. T. Soussi and K. G. Wiman, “Shaping genetic alterations in human cancer: the p53 mutation paradigm,” Cancer Cell, vol. 12, no. 4, pp. 303–312, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. W. A. Freed-Pastor and C. Prives, “Mutant p53: one name, many proteins,” Genes & Development, vol. 26, no. 12, pp. 1268–1286, 2012. View at Publisher · View at Google Scholar · View at Scopus
  19. E.-W. Lee, M.-S. Lee, S. Camus et al., “Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis,” The EMBO Journal, vol. 28, no. 14, pp. 2100–2113, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. Y. Xia, R. C. Padre, T. H. De Mendoza, V. Bottero, V. B. Tergaonkar, and I. M. Verma, “Phosphorylation of p53 by IκB kinase 2 promotes its degradation by β-TrCP,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 8, pp. 2629–2634, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. M. Pier Jr., Z. Ni, D. C. McMullen, and K. B. Storey, “Expression of Nrf2 and its downstream gene targets in hibernating 13-lined ground squirrels, Spermophilus tridecemlineatus,” Molecular and Cellular Biochemistry, vol. 312, no. 1-2, pp. 121–129, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. M. E. Allan and K. B. Storey, “Expression of NF-κB and downstream antioxidant genes in skeletal muscle of hibernating ground squirrels, Spermophilus tridecemlineatus,” Cell Biochemistry and Function, vol. 30, no. 2, pp. 166–174, 2012. View at Publisher · View at Google Scholar · View at Scopus
  23. C.-W. Wu and K. B. Storey, “FoxO3a-mediated activation of stress responsive genes during early torpor in a mammalian hibernator,” Molecular and Cellular Biochemistry, vol. 390, no. 1-2, pp. 185–195, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. P. Pan, M. D. Treat, and F. van Breukelen, “A systems-level approach to understanding transcriptional regulation by p53 during mammalian hibernation,” Journal of Experimental Biology, vol. 217, no. 14, pp. 2489–2498, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. F. van Breukelen, N. Sonenberg, and S. L. Martin, “Seasonal and state-dependent changes of eIF4E and 4E-BP1 during mammalian hibernation: Implications for the control of translation during torpor,” American Journal of Physiology—Regulatory Integrative and Comparative Physiology, vol. 287, no. 2, pp. R349–R353, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. C. R. Berkers, O. D. K. Maddocks, E. C. Cheung, I. Mor, and K. H. Vousden, “Metabolic regulation by p53 family members,” Cell Metabolism, vol. 18, no. 5, pp. 617–633, 2013. View at Publisher · View at Google Scholar · View at Scopus
  27. K. A. Cimprich and D. Cortez, “ATR: an essential regulator of genome integrity,” Nature Reviews Molecular Cell Biology, vol. 9, no. 8, pp. 616–627, 2008. View at Publisher · View at Google Scholar
  28. M. McVean, H. Xiao, K.-I. Isobe, and J. C. Pelling, “Increase in wild-type p53 stability and transactivational activity by the chemopreventive agent apigenin in keratinocytes,” Carcinogenesis, vol. 21, no. 4, pp. 633–639, 2000. View at Publisher · View at Google Scholar · View at Scopus
  29. M. A. Al-Mohanna, H. H. Al-Khalaf, N. Al-Yousef, and A. Aboussekhra, “The p16INK4a tumor suppressor controls p21WAF1 induction in response to ultraviolet light,” Nucleic Acids Research, vol. 35, no. 1, pp. 223–233, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. A. Matheu, C. Pantoja, A. Efeyan et al., “Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging,” Genes & Development, vol. 18, no. 22, pp. 2736–2746, 2004. View at Publisher · View at Google Scholar · View at Scopus
  31. E. Andres-Mateos, R. Mejias, A. Soleimani et al., “Impaired skeletal muscle regeneration in the absence of fibrosis during hibernation in 13-lined ground squirrels,” PLoS ONE, vol. 7, no. 11, Article ID e48884, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. Z. J. P. Yang, D. K. Broz, W. L. Noderer et al., “p53 Suppresses muscle differentiation at the myogenin step in response to genotoxic stress,” Cell Death & Differentiation, vol. 22, pp. 560–573, 2015. View at Publisher · View at Google Scholar · View at Scopus
  33. S. N. Tessier and K. B. Storey, “Expression of myocyte enhancer factor-2 and downstream genes in ground squirrel skeletal muscle during hibernation,” Molecular and Cellular Biochemistry, vol. 344, no. 1-2, pp. 151–162, 2010. View at Publisher · View at Google Scholar · View at Scopus
  34. Y. A. Zhan, H. Wu, A. T. Powell, G. W. Daughdrill, and F. M. Ytreberg, “Impact of the K24N mutation on the transactivation domain of p53 and its binding to murine double-minute clone 2,” Proteins, vol. 81, no. 10, pp. 1738–1747, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. B. Vogelstein, D. Lane, and A. J. Levine, “Surfing the p53 network,” Nature, vol. 408, no. 6810, pp. 307–310, 2000. View at Publisher · View at Google Scholar · View at Scopus
  36. I. Seim, X. Fang, Z. Xiong et al., “Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii,” Nature Communications, vol. 4, article 2212, 2013. View at Publisher · View at Google Scholar · View at Scopus
  37. M. de La Roche, S. N. Tessier, and K. B. Storey, “Structural and functional properties of glycerol-3-phosphate dehydrogenase from a mammalian hibernator,” Protein Journal, vol. 31, no. 2, pp. 109–119, 2012. View at Publisher · View at Google Scholar · View at Scopus