Biochemistry Research International

Research Article

Novel 4-Thiazolidinone Derivatives as Anti-Infective Agents: Synthesis, Characterization, and Antimicrobial Evaluation

Table 2

Mean diameter of zone of inhibition (mm) of synthesized compounds (4a–4f), standard and control against various microorganisms.
S. numberCompounds Conc. (μg/mL)Gram +ve strainsGram –ve strainsFungal strains
SABSBPMLPAPFEC AN PC
1 
(4a-C18H18FN3OS) 		50
100
200
400
800
1600		8
9
10
10
11
14		10
11
11
12
13
14		8
9
12
16
18
20		10
10
12
13
14
14		8
10
13
14
16
18		14
14
16
17
18
19		8
10
12
13
13
14		8
10
11
12
13
14		9
10
11
13
15
17
2 
(4b-C22H21N3OS)		50
100
200
400
800
1600		8
13
14
15
16
18		12
13
15
16
17
19		13
14
15
17
18
20		15
16
17
18
19
21		12
13
14
15
17
19		12
13
15
16
17
19		8
12
14
15
16
18		12
14
16
17
18
19		12
13
14
15
17
18
3 
(4c-C19H21N3O2S)		50
100
200
400
800
1600		8
8
8
8
10
12		8
8
12
14
15
16		8
10
14
16
18
20		8
8
10
13
14
14		9
12
13
14
15
16		10
12
14
15
16
18		10
10
13
14
14
15		 8
8
10
12
13
14		10
11
13
15
16
17
4 
(4d-C18H19N3O2S)		50
100
200
400
800
1600		8
13
15
17
19
21		13
14
15
17
18
19		12
13
14
16
17
18		14
16
17
18
19
20		15
16
17
18
19
20		13
14
15
16
17
19		12
13
15
16
18
20		8
12
13
14
16
18		8
12
14
16
17
19
5 
(4e-C16H17N3O2S)		50
100
200
400
800
1600		12
13
14
15
16
17		14
15
16
20
21
24		12
13
15
16
18
19		13
15
16
17
19
20		8
13
14
15
17
19		8
13
14
16
17
18		8
13
14
15
17
19		8
13
14
15
17
18		12
13
14
16
17
19
6 
(4f-C14H15N3OS2)		50
100
200
400
800
1600		8
9
10
12
13
15		9
10
12
14
16
18		8
8
10
12
18
21		8
8
8
10
12
14		10
12
16
18
20
21		10
14
16
17
18
19		8
10
12
14
14
16		8
8
10
12
14
17		8
10
12
13
15
18
7Norfloxacin1025223024262527——
8Fluconazole10———————2223
9Control (10% DMSO)——————————
BS: B. subtilis, SA: S. aureus, BP: B. pumilus, ML: M. luteus, PA: P. aeruginosa, EC: E. coli, PF: P. fluorescens, AN: A. niger, PC: P. chrysogenum, control = 10% v/v DMSO, and (—) = no activity.