Synthesis and Evaluation of In Vitro Antibacterial and Antitumor Activities of Novel N,N-Disubstituted Schiff Bases

Table 1

Antibacterial activity of the three compounds (100 μmol/L) against six strains in vitro.

Compounds	Inhibition rate (%)
	E. coli ATCC 25922	B. subtilis ATCC 6051	S. aureus ATCC 25923	A. baumannii ATCC BAA-1710D	K. pneumonia ATCC BAA-1705	P. aeruginosa ATCC 39324
1a	11.33 ± 7.24	Inactive	91.51 ± 7.98	8.51 ± 1.35	5.03 ± 2.36	Inactive
1b	16.55 ± 4.22	Inactive	Inactive	10.05 ± 2.46	8.07 ± 1.23	1.38 ± 1.26
1c	0.55 ± 2.19	Inactive	Inactive	14.40 ± 3.59	13.54 ± 4.58	8.65 ± 3.58
Ampicillin	99.34 ± 3.26	—	—	—	—	—
Streptomycin	—	94.12 ± 6.56	97.05 ± 4.24	—	—	—
Kanamycin	—	—			87.34 ± 3.19	—
Chloramphenicol	—	—	—	82.43 ± 9.29	—	86.65 ± 7.37

Values are mean ± standard deviation of three independent experiments. The bacteria were seeded in 96-well microplates at concentration of 1 × 10⁵ CFU/mL in Luria Broth medium. Tested compounds and positive controls were added to a final concentration of 100 μmol/L. Inhibiting growth of the bacteria was determined at 450 nm using an ELISA plate reader after shaking on a vibrating platform at 37°C for 8 h. compared with the control.