The Protective Effect of Naringenin-Oxime on Cisplatin-Induced Toxicity in Rats

Table 1

Effects of cisplatin (7 mg/kg), naringenin oxime (20 mg/kg), Cis + NOX₂₀, and Cis + NOX₄₀ on catalase activities, MDA, and GSH level in serum, kidney, and liver of rats.

	MDA			GSH			CATALASE
	Serum; (nmol/ml)	Kidney; (nmol/g)	Liver; (nmol/g)	Serum; (nmol/ml)	Kidney; (nmol/g)	Liver; (nmol/g)	Serum; (k/µg protein)	Kidney; (k/µg protein)	Liver; (k/µg protein)
Control	10,7 ± 0,	10,9 ± 1,	8,03 ± 0,9	7,3 ± 1,	7,7 ± 1,	13,13 ± 3,2	9,18 ± 2,1	2,8 ± 0,	5,76 ± 0,6
Cis	19,3 ± 5,	19,6 ± 2,	15,56 ± 2,7	3,4 ± 0,	4,8 ± 1,	8,23 ± 1,8	5,85 ± 0,8	1,2 ± 0,	3,03 ± 0,6
Cis + NOX20	14,7 ± 2,9	16,8 ± 1,	11,22 ± 1,4	5,1 ± 1,3	6,3 ± 1,4	9,99 ± 0,85	7,28 ± 1,8	1,9 ± 0,	4,29 ±1,37
Cis + NOX40	12,5 ± 2,	12,1 ± 1,	9,85 ± 0,9	6,3 ± 1,	7,1 ± 0,	12,11 ± 1,5	8,02 ± 1,44	2,2 ± 0,	4,84 ± 1,22
NOX20	9,9 ± 1,	9,5 ± 2,	8,06 ± 1,7	7,3 ± 0,	7,7 ± 0,	13,01 ± 1,4	9,03 ± 2,1	2,3 ± 0,	5,33 ± 0,6
value	0,000	0,000	0,000	0,000	0,000	0,000	0,000	0,000	0,013

Values are given as the means ± SD. There were no significant differences between the Cis and control groups in terms of any parameter (). , compared with the control group. , groups in which Cis and NOX are treated together compared with the Cis group.