Integrated Analysis of Oncogenic Networks in Colorectal Cancer Identifies GUCA2A as a Molecular Marker

Figure 4

Aberrant expression of GUCA2A can be a candidate prognostic biomarker in CRC. (a) Venn diagram of the robust DEGs and genes in the red module revealed 19 interacting genes. Set 1: hub genes in the red module; Set 2: downregulated DEGs. (b) Five-year OS of CRC patients from the TCGA database (). Patients with a low expression of GUCA2A have a significantly shorter OS. (c) GUCA2A expression in the TCGA database. (d) GUAC2A expression between CRC tissues and normal tissues in the six datasets. (e) GUAC2A expression in different tissue histology. (f) CRC cells in GSE68468. (g) GUCA2A expression levels in human CRC and their matched adjacent normal tissues. (h) ROC curves of tissue GUCA2A expression for differentiating CRC tissue from normal tissue. .

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