Research Article

Integrated Analysis of Oncogenic Networks in Colorectal Cancer Identifies GUCA2A as a Molecular Marker

Table 1

Whole DEGs (176 upregulated genes and 288 downregulated genes) identified in the six microarray data from the GEO database by using and |logFC| ≥ 1 as the cutoff criteria.

Name valueLogFC

Upregulated DEGs
MMP71.04E − 162.71E − 123.717319
THBS23.32E − 168.67E − 122.821997
TGFBI7.96E − 162.08E − 112.584099
MMP31.59E − 154.15E − 112.998933
DPEP14.59E − 151.20E − 103.250292
CDH34.60E − 141.20E − 093.266416
KRT231.55E − 134.05E − 093.658825
NFE2L31.32E − 123.45E − 082.149137
GZMB1.36E − 123.55E − 082.078558
COL11A13.42E − 128.95E − 082.728714
CXCL13.70E − 129.65E − 082.210194
CEMIP4.96E − 121.30E − 072.894223
FAP5.19E − 121.36E − 072.449763
SLCO1B36.55E − 121.71E − 072.197776
CLDN17.48E − 121.95E − 072.916603
MYC1.15E − 112.99E − 071.831720
IFITM11.15E − 112.99E − 071.625712
TESC2.53E − 116.61E − 072.108654
CXCL112.95E − 117.70E − 071.989137
EDNRA3.02E − 117.89E − 071.496142
MMP13.29E − 118.60E − 072.399938
FOXQ15.40E − 111.41E − 062.749133
TPX25.42E − 111.41E − 061.634694
COL4A15.77E − 111.51E − 061.630033
TCN17.96E − 112.08E − 061.926601
EGFL69.09E − 112.38E − 061.752245
TRIP139.50E − 112.48E − 061.729510
PMAIP11.01E − 102.63E − 061.621771
CXCL31.19E − 103.10E − 061.933844
PSAT11.33E − 103.48E − 061.749995
CTHRC11.36E − 103.56E − 062.547903
PLS31.76E − 104.61E − 061.561012
INHBA1.82E − 104.76E − 062.470231
IFITM22.22E − 105.81E − 061.477155
PHLDA12.77E − 107.25E − 062.025229
CSE1L2.77E − 107.25E − 061.509054
BMP44.28E − 101.12E − 051.311002
CRNDE4.93E − 101.29E − 052.196882
S100A95.05E − 101.32E − 051.793278
CDK46.20E − 101.62E − 051.268501
XPOT6.54E − 101.71E − 051.350678
LY6E6.54E − 101.71E − 051.773015
CCL208.45E − 102.21E − 051.681642
TSPAN58.63E − 102.25E − 051.300671
CDC25B9.62E − 102.51E − 051.477785
LGR51.03E − 092.69E − 051.765688
ASCL21.06E − 092.78E − 052.270850
IFITM31.12E − 092.94E − 051.535829
PLAU1.35E − 093.52E − 051.449998
RIPK21.40E − 093.65E − 051.304180
COL5A21.42E − 093.72E − 051.709418
CXCL101.45E − 093.78E − 051.832510
DUSP141.49E − 093.89E − 051.604280
TRIB31.52E − 093.97E − 052.009118
CKMT21.71E − 094.46E − 052.047320
CEL1.77E − 094.62E − 051.921534
TGIF21.82E − 094.74E − 051.594622
HOMER11.89E − 094.94E − 051.595741
SRPX21.97E − 095.15E − 051.759897
SLC7A52.05E − 095.37E − 051.907805
UBD2.06E − 095.38E − 051.848031
GPSM22.90E − 097.58E − 051.310352
AZGP13.52E − 099.20E − 052.058214
AURKA3.81E − 099.96E − 051.248453
STC23.90E − 090.0001021.838371
SULF13.90E − 090.0001022.003268
ATAD24.09E − 090.0001071.500415
TMEM1584.11E − 090.0001071.212075
PPAT4.12E − 090.0001081.305250
SPP14.13E − 090.0001082.205887
CXCL24.36E − 090.0001141.826375
COL1A24.44E − 090.0001161.882105
SLC7A115.29E − 090.0001381.208023
TIMP15.69E − 090.0001491.661168
MMP126.08E − 090.0001591.933314
SCD6.11E − 090.0001601.564105
SOX96.43E − 090.0001681.352557
CXCL96.92E − 090.0001811.461166
HSPH18.01E − 090.0002091.238503
GDPD58.12E − 090.0002121.308392
CXCL88.27E − 090.0002162.588362
COL1A18.38E − 090.0002191.769908
FABP68.52E − 090.0002232.079844
PMEPA18.52E − 090.0002231.333566
ANXA99.83E − 090.0002571.608179
TDGF1P31.15E − 080.0003011.841176
CEP551.22E − 080.0003191.470764
COL10A11.27E − 080.0003311.780470
MCM101.37E − 080.0003581.211513
MPP61.51E − 080.0003961.432320
PROX11.58E − 080.0004131.364230
TEAD41.65E − 080.0004311.447381
CLDN21.72E − 080.0004491.698260
ODAM1.79E − 080.0004681.471032
MTHFD21.83E − 080.0004781.111261
KRT6B1.85E − 080.0004841.485079
HILPDA1.87E − 080.0004881.488635
DACH12.14E − 080.0005591.610398
ESM12.17E − 080.0005681.708858
CYP4X12.22E − 080.0005811.382114
GNG42.25E − 080.0005881.178933
ARID3A2.35E − 080.0006131.275140
PPBP2.38E − 080.0006211.748166
EPHX42.42E − 080.0006332.381989
LRP82.67E − 080.0006971.522085
PTP4A32.67E − 080.0006971.183443
SERPINE22.67E − 080.0006971.154912
AGT2.81E − 080.0007341.405610
C22.84E − 080.0007431.372973
RRM22.86E − 080.0007481.196973
NEBL3.49E − 080.0009121.521795
RPP403.49E − 080.0009121.285132
ARNTL23.77E − 080.0009841.419157
AHCY3.84E − 080.0010041.237807
GTF2IRD13.95E − 080.0010321.371062
WNT24.00E − 080.0010441.452032
TOP2A4.04E − 080.0010571.372624
PUS74.09E − 080.0010691.249772
NMU4.30E − 080.0011221.284463
COL6A34.44E − 080.0011601.270615
RNF434.57E − 080.0011951.397306
COL5A14.69E − 080.0012261.191502
CDK14.70E − 080.0012281.317782
ETV44.86E − 080.0012712.204983
PTGS25.04E − 080.0013171.233879
CHEK15.20E − 080.0013581.126745
MMP105.41E − 080.0014141.195256
FZD35.52E − 080.0014421.089222
UBE2C5.81E − 080.0015181.241558
RNASEH2A6.16E − 080.0016091.071208
ENC16.27E − 080.0016371.375197
IGF2BP36.37E − 080.0016651.082776
VSNL16.75E − 080.0017641.786437
GALNT66.79E − 080.0017741.266153
ERP276.97E − 080.0018211.218536
PROCR7.73E − 080.0020201.376152
PAFAH1B37.88E − 080.0020581.100418
RFC38.14E − 080.0021261.372173
NKRF8.14E − 080.0021271.043072
CXCL59.69E − 080.0025311.294918
SQLE1.03E − 070.0027001.308167
EXOSC51.08E − 070.0028281.132422
S100P1.13E − 070.0029441.551099
ELOVL51.27E − 070.0033311.176539
ZAK1.29E − 070.0033601.541699
TCFL51.45E − 070.0037861.270140
LAPTM4B1.67E − 070.0043761.026874
CEBPB1.70E − 070.0044311.333258
SLCO4A11.83E − 070.0047901.606904
TTK1.89E − 070.0049341.386804
TMEM971.98E − 070.0051791.082142
CHI3L12.01E − 070.0052391.621308
PPM1H2.10E − 070.0054751.353835
SORD2.14E − 070.0055911.037586
CST12.20E − 070.0057471.894531
CENPF2.46E − 070.0064221.024242
GTF3A2.47E − 070.0064511.215577
APCDD12.59E − 070.0067721.580775
KIF4A2.59E − 070.0067721.267447
MFAP22.65E − 070.0069141.397671
CCNB12.77E − 070.0072411.203637
GDF152.88E − 070.0075141.563948
NXT12.93E − 070.0076671.046948
SHMT22.95E − 070.0076971.002641
SNTB12.96E − 070.0077261.291950
TACSTD22.97E − 070.0077541.640872
SNX102.99E − 070.0078141.021758
SLC12A23.04E − 070.0079331.134681
TNFRSF12A3.13E − 070.0081901.332447
SLC5A63.25E − 070.0084881.064032
RUVBL13.26E − 070.0085131.066507
FXYD53.32E − 070.0086801.172860
ZNF2393.35E − 070.0087451.158161
REG1A3.40E − 070.0088761.168719
OLFML2B3.57E − 070.0093261.332885
ERCC6L3.63E − 070.0094721.325393

Downregulated DEGs
GUCA2B4.94E − 211.29E − 16−5.47325
GUCA2A5.63E − 201.47E − 15−4.98756
CA49.10E − 202.38E − 15−4.93587
MS4A122.15E − 195.61E − 15−5.22647
CA23.16E − 198.27E − 15−4.64843
AQP87.18E − 191.88E − 14−5.22336
CLCA11.67E − 174.37E − 13−4.41598
CLCA42.30E − 176.01E − 13−5.78604
AKR1B103.47E − 179.06E − 13−3.66480
CA11.37E − 163.58E − 12−4.85127
HSD17B21.42E − 153.72E − 11−3.65299
GCG1.86E − 154.87E − 11−4.24507
CWH433.10E − 158.09E − 11−3.35700
MT1M6.63E − 151.73E − 10−3.74527
CHP26.63E − 151.73E − 10−3.59700
FCGBP9.37E − 152.45E − 10−3.35836
ADH1C1.89E − 144.93E − 10−3.66678
CD1777.18E − 141.88E − 09−3.56989
CA121.04E − 132.73E − 09−2.48416
CHGA1.04E − 132.73E − 09−3.21194
SLC26A31.09E − 132.85E − 09−3.26689
CEACAM71.16E − 133.02E − 09−3.26188
PLAC81.75E − 134.58E − 09−2.93747
CLDN81.79E − 134.67E − 09−4.07661
PCK13.95E − 131.03E − 08−2.41432
BEST25.80E − 131.52E − 08−2.88517
GBA36.08E − 131.59E − 08−3.15495
MT1H7.81E − 132.04E − 08−2.45079
HMGCS21.28E − 123.35E − 08−2.63704
SI1.53E − 123.99E − 08−3.18335
GCNT31.86E − 124.87E − 08−2.55705
EDN32.02E − 125.29E − 08−2.36855
SLC26A22.58E − 126.74E − 08−2.74311
TSPAN13.02E − 127.89E − 08−2.43173
UGT2B173.26E − 128.51E − 08−2.68448
BCAS13.43E − 128.96E − 08−2.14870
LRRC194.61E − 121.20E − 07−2.60514
LGALS25.96E − 121.56E − 07−2.50281
ANPEP8.52E − 122.23E − 07−2.96251
VSIG28.52E − 122.23E − 07−2.90829
MT1E9.09E − 122.37E − 07−2.30341
MT1G9.49E − 122.48E − 07−2.13170
NXPE49.66E − 122.53E − 07−2.93788
KRT209.69E − 122.53E − 07−2.12657
CA71.29E − 113.38E − 07−2.72816
MT1F1.32E − 113.45E − 07−2.15911
KLF41.38E − 113.59E − 07−2.38010
AHCYL21.43E − 113.74E − 07−2.24169
ITLN11.74E − 114.55E − 07−3.42798
HSD11B22.10E − 115.49E − 07−2.34259
NR3C22.53E − 116.60E − 07−2.37317
EPB41L32.57E − 116.72E − 07−2.39867
ITM2C2.67E − 116.97E − 07−2.12884
MMP282.86E − 117.48E − 07−1.93771
ZG163.09E − 118.06E − 07−4.23120
ABCG23.75E − 119.80E − 07−3.20141
SLC4A44.13E − 111.08E − 06−3.28247
SCGB2A14.33E − 111.13E − 06−2.48958
MALL4.61E − 111.20E − 06−2.29999
TUBAL34.92E − 111.29E − 06−2.39086
RUNDC3B5.33E − 111.39E − 06−1.89913
NR1H45.50E − 111.44E − 06−2.46055
SLC30A105.68E − 111.48E − 06−3.22414
PIGR6.05E − 111.58E − 06−2.18018
MUC26.24E − 111.63E − 06−2.62907
HPGD6.74E − 111.76E − 06−2.64497
TSPAN76.84E − 111.79E − 06−2.30396
PAPSS21.30E − 103.39E − 06−1.78856
SLC17A41.31E − 103.43E − 06−2.31184
DHRS91.36E − 103.56E − 06−2.74003
CAPN91.65E − 104.32E − 06−1.77713
PTPRH1.70E − 104.43E − 06−1.93474
SST1.81E − 104.73E − 06−2.35448
HEPACAM21.82E − 104.76E − 06−2.85009
SMPDL3A2.03E − 105.31E − 06−1.85516
UGT2A32.16E − 105.65E − 06−2.42200
TRPM62.42E − 106.34E − 06−2.40017
CES22.58E − 106.74E − 06−1.80950
NR5A22.64E − 106.91E − 06−1.65550
DHRS112.77E − 107.25E − 06−2.40964
ENTPD52.88E − 107.52E − 06−1.91140
PLCL22.98E − 107.79E − 06−1.71267
MYO1A2.98E − 107.79E − 06−1.82841
BTNL83.28E − 108.58E − 06−2.68136
PLCD13.40E − 108.88E − 06−1.69423
ADTRP3.71E − 109.69E − 06−2.66899
ARL144.37E − 101.14E − 05−2.10661
PDZD34.78E − 101.25E − 05−1.73340
SCNN1B5.25E − 101.37E − 05−2.51853
MEP1A5.25E − 101.37E − 05−2.15953
C2orf885.40E − 101.41E − 05−2.60606
GPA335.69E − 101.49E − 05−1.85470
SCIN6.20E − 101.62E − 05−2.19971
MAOA6.61E − 101.73E − 05−1.79573
PIGZ6.89E − 101.80E − 05−1.67717
PYY6.96E − 101.82E − 05−2.53788
C4orf197.26E − 101.90E − 05−1.57357
TNFRSF177.47E − 101.95E − 05−2.36650
ADAMDEC17.47E − 101.95E − 05−2.39500
TEX118.71E − 102.28E − 05−2.24440
CDHR29.44E − 102.47E − 05−1.71114
TMEM1719.64E − 102.52E − 05−2.11860
STMN21.28E − 093.36E − 05−2.05581
PKIB1.45E − 093.78E − 05−2.98037
CLIC51.57E − 094.11E − 05−1.55858
BMP21.60E − 094.19E − 05−1.76798
RETSAT1.63E − 094.26E − 05−1.68389
PADI21.69E − 094.42E − 05−2.10023
SLC9A21.80E − 094.70E − 05−1.55732
CYP2C182.16E − 095.65E − 05−1.71017
C1orf1152.32E − 096.05E − 05−1.74460
CEACAM12.42E − 096.31E − 05−1.84011
PDE9A2.44E − 096.37E − 05−2.05665
SLCO2A12.58E − 096.75E − 05−1.53024
BCAR32.63E − 096.87E − 05−1.50716
METTL7A2.65E − 096.92E − 05−1.62515
DSC22.65E − 096.92E − 05−1.44448
IL1R22.75E − 097.19E − 05−2.16852
CCDC682.75E − 097.19E − 05−1.89156
GDPD32.78E − 097.28E − 05−2.08667
PDE6A2.81E − 097.34E − 05−1.93721
EPHX23.12E − 098.16E − 05−1.49186
SPIB3.35E − 098.76E − 05−2.27898
ITPKA3.41E − 098.91E − 05−1.62863
SCUBE23.66E − 099.57E − 05−1.51582
AMPD14.13E − 090.000108−1.81548
SELENBP14.61E − 090.000120−2.04099
TFCP2L15.10E − 090.000133−1.16817
BTNL35.13E − 090.000134−2.10512
VIPR15.45E − 090.000142−1.57631
ZZEF15.53E − 090.000144−1.27744
NAT25.61E − 090.000147−1.61058
CDHR55.81E − 090.000152−1.97788
PTGDR6.44E − 090.000168−2.08658
HHLA27.58E − 090.000198−1.91952
PLCE17.60E − 090.000199−1.63459
BEST47.87E − 090.000206−2.37175
FUCA18.12E − 090.000212−1.41919
FGFBP18.12E − 090.000212−1.45128
MT1X8.24E − 090.000215−1.87572
SLC16A98.52E − 090.000223−1.97426
SEMA6A8.52E − 090.000223−1.66469
FXYD38.58E − 090.000224−1.39744
DEFB18.94E − 090.000233−1.76340
ACADS9.22E − 090.000241−1.70299
UGDH9.50E − 090.000248−1.45862
HRASLS21.06E − 080.000276−1.48365
CYP4F121.09E − 080.000284−1.26493
JCHAIN1.10E − 080.000288−2.33454
ABHD31.13E − 080.000295−1.54939
VWA5A1.23E − 080.000321−1.12976
LDHD1.27E − 080.000332−2.10259
XDH1.28E − 080.000334−1.53406
INSL51.29E − 080.000337−2.42430
SPINK51.38E − 080.000359−2.43812
VILL1.50E − 080.000391−1.41689
SQRDL1.51E − 080.000396−1.38225
FABP21.52E − 080.000398−1.88374
LGALS41.61E − 080.000421−1.42830
DNASE1L31.65E − 080.000431−1.82008
SLC44A41.66E − 080.000434−1.59136
GOLM11.68E − 080.000439−1.20581
RNF1861.72E − 080.000450−1.21896
GDPD21.85E − 080.000484−1.90186
SLC22A18AS1.85E − 080.000484−1.62665
MGLL1.91E − 080.000499−1.32867
B3GNT61.92E − 080.000501−1.59112
IL6R1.92E − 080.000502−1.86011
RAPGEFL11.92E − 080.000502−1.32000
TRPM41.94E − 080.000508−1.34414
ETFDH2.00E − 080.000522−1.52397
TMPRSS22.05E − 080.000536−1.39816
APOBR2.08E − 080.000544−1.69871
APPL22.11E − 080.000551−1.46951
IQGAP22.17E − 080.000566−1.55628
FAM83E2.17E − 080.000568−1.17487
ETHE12.29E − 080.000599−1.61458
FLVCR22.39E − 080.000624−1.01211
ALDH1A12.41E − 080.000631−1.28928
DENND2A2.51E − 080.000657−1.32793
HRCT12.57E − 080.000671−1.58787
ATP8B12.69E − 080.000703−1.00964
A1CF2.74E − 080.000715−1.36877
ELOVL62.96E − 080.000773−1.08274
C11orf863.02E − 080.000789−2.11210
TMEM1003.14E − 080.000821−1.69604
ASAP33.27E − 080.000854−1.44474
S100A143.29E − 080.000859−1.21353
PHLPP23.42E − 080.000892−1.45264
LIMA13.47E − 080.000907−1.20588
FABP13.51E − 080.000916−1.62316
FMO53.62E − 080.000947−1.41152
LRMP3.64E − 080.000950−1.84646
UGP23.68E − 080.000961−1.28750
ATP2A33.74E − 080.000978−1.51001
SLC22A53.74E − 080.000978−1.30616
FAM46C3.78E − 080.000989−1.41521
LXN3.97E − 080.001037−1.10935
CDKN2B3.98E − 080.001039−2.23550
HMOX13.99E − 080.001043−1.23547
NEDD4L4.03E − 080.001054−1.23680
CLDN74.18E − 080.001093−1.29905
PARM14.21E − 080.001099−1.52095
HSD3B24.29E − 080.001120−2.26639
KIAA05134.39E − 080.001146−1.22322
ACADVL4.50E − 080.001176−1.23429
SYTL24.74E − 080.001238−1.07640
SLC1A14.79E − 080.001251−1.40176
CNTN34.81E − 080.001256−2.13362
CNNM44.97E − 080.001300−1.36807
CASP75.04E − 080.001317−1.34691
GLTP5.30E − 080.001385−1.40471
PGM15.49E − 080.001435−1.23037
ERN25.60E − 080.001464−1.10843
NAAA5.72E − 080.001494−1.45647
GNA116.10E − 080.001593−1.40416
CCL236.37E − 080.001665−1.50079
STYK16.40E − 080.001673−1.56848
CFD6.56E − 080.001715−1.80374
C15orf486.82E − 080.001783−1.45026
OASL6.89E − 080.001800−1.13508
GPT6.99E − 080.001827−1.44289
CLDN237.12E − 080.001859−1.93577
MB7.62E − 080.001991−1.42542
HIGD1A7.65E − 080.002000−1.40813
EMP18.37E − 080.002188−1.46200
ADH1B8.46E − 080.002211−2.01430
LPAR18.49E − 080.002219−1.26559
GPAT38.70E − 080.002272−2.01808
CHGB8.90E − 080.002324−1.55043
P3H29.09E − 080.002376−1.48288
PRKACB9.28E − 080.002424−1.46492
OSBPL1A9.84E − 080.002572−1.16940
SPINK41.04E − 070.002716−1.69181
MT2A1.04E − 070.002726−1.55590
SULT1B11.07E − 070.002807−1.66731
NAT11.08E − 070.002828−1.17391
ADRA2A1.11E − 070.002892−1.54370
MEP1B1.13E − 070.002960−2.16734
LPCAT41.18E − 070.003077−1.02702
PCSK71.18E − 070.003077−1.00185
ST6GALNAC11.18E − 070.003088−1.65355
SGK21.21E − 070.003160−1.41158
GRAMD31.26E − 070.003287−1.25518
RIOK31.27E − 070.003331−1.21281
CITED21.29E − 070.003374−1.11561
CXCL121.41E − 070.003684−1.54414
ITM2A1.45E − 070.003786−1.47880
SEPP11.51E − 070.003956−1.10723
KBTBD111.53E − 070.004006−1.05544
RHOF1.55E − 070.004040−1.11757
GSTA11.57E − 070.004105−1.34829
GALNT121.61E − 070.004214−1.23449
BCHE1.70E − 070.004446−1.57410
HGD1.78E − 070.004657−1.24750
HOXD11.83E − 070.004793−1.79058
FGL21.90E − 070.004977−1.31339
ATP8A12.03E − 070.005307−1.05015
HIST1H1C2.06E − 070.005393−1.25170
MYOT2.10E − 070.005480−1.72660
PBLD2.11E − 070.005502−1.58127
RBM472.15E − 070.005614−1.08864
CES32.18E − 070.005700−1.45856
CD1D2.18E − 070.005704−1.29631
FAM150B2.19E − 070.005719−1.50655
RARRES12.23E − 070.005819−1.46770
LGALS92.24E − 070.005842−1.01981
KLK12.27E − 070.005936−1.29450
TOX2.27E − 070.005942−1.29132
ACVRL12.36E − 070.006175−1.13083
CPT22.44E − 070.006372−1.22566
SGK12.57E − 070.006718−1.64587
ALPI2.62E − 070.006834−1.09455
SLC51B2.65E − 070.006919−2.27581
SLC20A12.71E − 070.007076−1.03315
SCGN2.74E − 070.007164−1.86108
ASPA2.75E − 070.007186−1.45497
FAM107B2.81E − 070.007337−1.24898
AGR32.82E − 070.007358−1.80558
HOXA52.85E − 070.007437−1.09160
NPY1R2.97E − 070.007754−1.92966
TNFSF102.97E − 070.007754−1.20956
FAM107A3.18E − 070.008318−1.40373
MUC43.26E − 070.008520−1.83234
TST3.31E − 070.008645−1.30505
NXPE13.57E − 070.009326−1.90526
SPON13.60E − 070.009400−1.78810
ST6GALNAC63.78E − 070.009874−1.79857

FC: fold change.