The Emerging Role of Rab5 in Membrane Receptor Trafficking and Signaling Pathways

Figure 1

Transformation of Rab proteins between the activated and inactivated forms. GAP catalyzes the hydrolysis of GTP and inactivates the Rab proteins. GDI stabilizes GDP-Rab. GEF removes GDP via guanine exchange, allowing Rab binding to GTP and further interacting with downstream effectors.