Research Article
The Efficacy of Pegylated Liposomal Doxorubicin-Based Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Case-Control Study in Taiwan
Table 4
Laboratory measurements for adverse effects monitoring reported in PLD and epirubicin groups.
| Measurements | Total (n = 366) | PLD (n = 183) | Epirubicin (n = 183) | | N | (%) | N | (%) | n | (%) |
| Leukocytes (μL) | | | | | | | 0.606 | ≥3500 | 208 | (59.8) | 105 | (60.3) | 103 | (59.2) | | ≥3000–3500 | 56 | (16.1) | 31 | (17.8) | 25 | (14.4) | | ≥2000–3000 | 69 | (19.8) | 33 | (19.0) | 36 | (20.7) | | ≥1000–2000 | 13 | (3.7) | 4 | (2.3) | 9 | (5.2) | | <1000 | 2 | (0.6) | 1 | (0.6) | 1 | (0.6) | |
| Absolute neutrophil count (mm3) | | | | | | | 0.510 | ≥2000 | 192 | (55.2) | 95 | (54.6) | 97 | (55.7) | | ≥1500–2000 | 82 | (23.6) | 44 | (25.3) | 38 | (21.8) | | ≥1000–1500 | 48 | (13.8) | 26 | (14.9) | 22 | (12.6) | | ≥500–1000 | 18 | (5.2) | 6 | (3.4) | 12 | (6.9) | | <500 | 8 | (2.3) | 3 | (1.7) | 5 | (2.9) | |
| Hemoglobin (g/dl) | | | | | | | <0.001 | ≥12 | 62 | (17.8) | 49 | (28.2) | 13 | (7.5) | | ≥10–12 | 195 | (56.0) | 91 | (52.3) | 104 | (59.8) | | ≥8–10 | 76 | (21.8) | 28 | (16.1) | 48 | (27.6) | | ≥6.5–8 | 12 | (3.4) | 5 | (2.9) | 7 | (4.0) | | <6.5 | 3 | (0.9) | 1 | (0.6) | 2 | (1.1) | |
| Platelets (μL) | | | | | | | 0.644 | ≥150000 | 339 | (97.4) | 169 | (97.1) | 170 | (97.7) | | ≥50000-75000 | 6 | (1.7) | 4 | (2.3) | 2 | (1.1) | | ≥1000-50000 | 2 | (0.6) | 1 | (0.6) | 1 | (0.6) | | <10000 | 1 | (0.3) | 0 | (0.0) | 1 | (0.6) | |
| AST (U/L) | | | | | | | 0.745 | ≤87.5 | 324 | (93.1) | 161 | (92.5) | 163 | (93.7) | | >87.5–100 | 7 | (2.0) | 3 | (1.7) | 4 | (2.3) | | >100–200 | 13 | (3.7) | 7 | (4.0) | 6 | (3.4) | | >200–800 | 4 | (1.1) | 3 | (1.7) | 1 | (0.6) | |
| ALT (U/L) | | | | | | | 0.490 | ≤87.5 | 294 | (84.5) | 145 | (83.3) | 149 | (85.6) | | >87.5–100 | 11 | (3.2) | 8 | (4.6) | 3 | (1.7) | | >100–200 | 32 | (9.2) | 16 | (9.2) | 16 | (9.2) | | >200–800 | 11 | (3.2) | 5 | (2.9) | 6 | (3.4) | |
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values are estimated using Fisher’s exact test. |