Flavonoid-Rich Extract of Dissotis rotundifolia Whole Plant Protects against Ethanol-Induced Gastric Mucosal Damage

Figure 2

Representative appearance of the gastric mucosa of rats pretreated with DRE and omeprazole before ulcer induction with ethanol. (a) Rats pretreated with vehicle without ulcerogen (normal control). Normal gastric mucosa appearance. (b) Rats treated with only ulcerogen without any form of drug pretreatment. Severe injuries (black arrows) were observed in the gastric mucosa. Extensive visible hemorrhage necrosis was observed. (c) Rats pretreated with 100 mg/kg DRE followed by ulcerogen (ethanol). Moderate injuries (black arrows) to mucosa were seen. (d) Rats pretreated with 300 mg/kg DRE followed by ulcerogen (ethanol). Mild injuries to mucosa were observed. (e) Rats pretreated with 500 mg/kg DRE followed by ulcerogen (ethanol). Moderate injuries to mucosa were observed though not as 100 mg/kg DRE followed by ulcerogen (ethanol). (f) Rats pretreated with omeprazole followed by ulcerogen (ethanol). Injuries to mucosa are much milder as 300 mg/kg DRE.

(a)

(b)

(c)

(d)

(e)

(f)