Research Article
Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population
Table 3
Distribution of four polymorphisms and the association with NIHL.
| Genetic models | Genotypes | Cases n = 1040 | Controls n = 1060 | | Adjusted OR (95% CI)a | Holm | SidakSS | SidakSD |
| rs2257082 | | n = 1030 | n = 1053 | | | | | |
| Codominant | AA | 324 | 380 | | 1.00 (ref) | | | | AG | 546 | 515 | 2.69E − 4 | 1.54 (1.22–1.94) | | | | GG | 160 | 158 | 1.51E − 3 | 1.73 (1.23–2.44) | | | |
| Dominant | AA | 324 | 380 | | 1.00 (ref) | | | | AG/GG | 706 | 673 | 2.09E − 4 | 1.55 (1.23–1.95) | | | |
| Recessive | AA/AG | 870 | 895 | | 1.00 (ref) | | | | GG | 160 | 158 | 0.26 | 1.16 (0.89–1.51) | | | |
| Alleles | A | 1194 | 1275 | | 1.00 (ref) | | | | G | 866 | 831 | 0.09 | 1.11 (0.98–1.26) | 0.18 | 0.314 | 0.172 | rs11077 | | n = 1036 | n = 1056 | | | | | |
| Codominant | TT | 835 | 921 | | 1.00 (ref) | | | | TG | 186 | 129 | 8E − 6 | 1.85 (1.41–2.43) | | | | GG | 15 | 6 | 7.1E − 3 | 3.66 (1.42–9.41) | | | |
| Dominant | TT | 835 | 921 | | 1.00 (ref) | | | | TG/GG | 201 | 135 | 1E − 6 | 1.93 (1.48–2.52) | | | |
| Recessive | TT/TG | 1021 | 1050 | | 1.00 (ref) | | | | GG | 15 | 6 | 2.04E − 2 | 3.03 (1.19–7.76) | | | |
| Alleles | T | 1856 | 1971 | | 1.00 (ref) | | | | G | 216 | 141 | 1.43E − 5 | 1.63 (1.30–2.03) | 5.71E − 5 | 5.71E − 5 | 5.71E − 5 | rs7755135 | | n = 1034 | n = 1057 | | | | | |
| Codominant | CC | 689 | 735 | | 1.00 (ref) | | | | CT | 305 | 302 | 0.12 | 1.19(0.95–1.49) | | | | TT | 40 | 20 | 6.19E − 4 | 2.70(1.53–4.77) | | | |
| Dominant | CC | 689 | 735 | | 1.00 (ref) | | | | CT/TT | 345 | 322 | 0.04 | 1.26(1.01–1.57) | | | |
| Recessive | CC/CT | 994 | 1037 | | 1.00 (ref) | | | | TT | 40 | 20 | 1.65E − 3 | 2.42(1.40–4.19) | | | |
| Alleles | C | 1683 | 1772 | | 1.00 (ref) | | | | T | 385 | 342 | 0.037 | 1.12 (1.01–1.39) | 0.112 | 0.141 | 0.108 | rs1106841 | | n = 1035 | n = 1052 | | | | | |
| Codominant | AA | 467 | 491 | | 1.00 (ref) | | | | AC | 483 | 463 | 0.18 | 1.16(0.93–1.44) | | | | CC | 85 | 98 | 0.88 | 0.97(0.67–1.40) | | | |
| Dominant | AA | 467 | 491 | | 1.00 (ref) | | | | AC/CC | 568 | 561 | 0.22 | 1.15(0.92–1.42) | | | |
| Recessive | AA/AC | 950 | 954 | | 1.00 (ref) | | | | CC | 85 | 98 | 0.35 | 0.86(0.62–1.18) | | | |
| Alleles | A | 1417 | 1445 | | 1.00 (ref) | | | | C | 653 | 659 | 0.88 | 1.01 (0.89–1.15) | 0.875 | 0.999 | 0.875 |
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aAdjusted for age, sex, smoking, and drinking in the logistic regression model.
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