Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population

Table 3

Distribution of four polymorphisms and the association with NIHL.

Genetic models	Genotypes	Cases n = 1040	Controls n = 1060		Adjusted OR (95% CI)^a	Holm	SidakSS	SidakSD
rs2257082		n = 1030	n = 1053
Codominant	AA	324	380		1.00 (ref)
	AG	546	515	2.69E − 4	1.54 (1.22–1.94)
	GG	160	158	1.51E − 3	1.73 (1.23–2.44)
Dominant	AA	324	380		1.00 (ref)
	AG/GG	706	673	2.09E − 4	1.55 (1.23–1.95)
Recessive	AA/AG	870	895		1.00 (ref)
	GG	160	158	0.26	1.16 (0.89–1.51)
Alleles	A	1194	1275		1.00 (ref)
	G	866	831	0.09	1.11 (0.98–1.26)	0.18	0.314	0.172
rs11077		n = 1036	n = 1056
Codominant	TT	835	921		1.00 (ref)
	TG	186	129	8E − 6	1.85 (1.41–2.43)
	GG	15	6	7.1E − 3	3.66 (1.42–9.41)
Dominant	TT	835	921		1.00 (ref)
	TG/GG	201	135	1E − 6	1.93 (1.48–2.52)
Recessive	TT/TG	1021	1050		1.00 (ref)
	GG	15	6	2.04E − 2	3.03 (1.19–7.76)
Alleles	T	1856	1971		1.00 (ref)
	G	216	141	1.43E − 5	1.63 (1.30–2.03)	5.71E − 5	5.71E − 5	5.71E − 5
rs7755135		n = 1034	n = 1057
Codominant	CC	689	735		1.00 (ref)
	CT	305	302	0.12	1.19(0.95–1.49)
	TT	40	20	6.19E − 4	2.70(1.53–4.77)
Dominant	CC	689	735		1.00 (ref)
	CT/TT	345	322	0.04	1.26(1.01–1.57)
Recessive	CC/CT	994	1037		1.00 (ref)
	TT	40	20	1.65E − 3	2.42(1.40–4.19)
Alleles	C	1683	1772		1.00 (ref)
	T	385	342	0.037	1.12 (1.01–1.39)	0.112	0.141	0.108
rs1106841		n = 1035	n = 1052
Codominant	AA	467	491		1.00 (ref)
	AC	483	463	0.18	1.16(0.93–1.44)
	CC	85	98	0.88	0.97(0.67–1.40)
Dominant	AA	467	491		1.00 (ref)
	AC/CC	568	561	0.22	1.15(0.92–1.42)
Recessive	AA/AC	950	954		1.00 (ref)
	CC	85	98	0.35	0.86(0.62–1.18)
Alleles	A	1417	1445		1.00 (ref)
	C	653	659	0.88	1.01 (0.89–1.15)	0.875	0.999	0.875

^aAdjusted for age, sex, smoking, and drinking in the logistic regression model.