Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population

Table 4

Frequencies of inferred haplotypes among the cases and controls and their association with risk NIHL.

Haplotypes^a	Case (freq)	Control (freq)	Chi2	Pearson’s	OR (95% CI)	Holm	SidakSS	SidakSD	Global p value
GGTA	199 (0.10)	136 (0.07)	14.21	1.63E − 04	1.54 (1.30–1.94)	8.16E − 04	8.16E − 04	8.16E − 04	1.55E − 06
GTTA	166 (0.08)	196 (0.09)	2.13	0.14	0.85 (0.69–1.06)	0.17	0.54	0.17
GTCA	261 (0.13)	320 (0.15)	5.71	0.02	0.81 (0.68–0.96)	0.05	0.08	0.05
GTCC	222 (0.11)	160 (0.08)	12.41	4.28E − 04	1.46 (1.18–1.81)	0.001	0.002	0.001
ATCC	1186 (0.58)	1264 (0.61)	2.93	0.09	0.90 (0.79–1.02)	0.17	0.37	0.17

^aThe alleles of the haplotypes were arrayed as rs2257082-rs11077-rs7755135-rs1106841. Haplotypes with frequency <0.03 are ignored.