Animal Models of Osteochondral Defect for Testing Biomaterials

Table 3

Examples of studies using rabbit osteochondral defect models.

Authors	Age/weight	Defect size (diameter × depth)	Location	Endpoint	Material tested
Liao et al. [42]	2–2.5 kg	4 mm × 3 mm	The trochlear groove	6, 12, and 18 weeks	CSMA/PECA/GO hybrid scaffold
Bauer et al. [43]	8 months	4 mm × 5 mm	The medial trochlear groove	4 and 12 weeks	Hyaluronic acid thioester
Ruan et al. [44]	6 months	4 mm × 3 mm	The medial trochlear groove	4, 8, and 12 weeks	SF/CS/nHA phase scaffold
Meng et al. [45]	4–6 months	4 mm × 2 mm	The trochlear groove	6, 12, and 24 weeks	AMP-E7/BM-MSC
Zhang et al. [46]	2.5–3 kg	4 mm × 4 mm	The patellar groove	6 and 12 weeks	COL-nanofiber and COL scaffolds