Animal Models of Osteochondral Defect for Testing Biomaterials

Table 5

Examples of studies using pig osteochondral defect models.

Authors	Age	Defect size (diameter × depth)	Location	Endpoint	Material tested
Christensen et al. [68]	19.8 months	6 mm × 8 mm	The medial trochlear and the lateral trochlear	6, 24 months	Autologous dual-tissue transplantation/autologous cartilage chips
Betsch et al. [66]	18–30 months	6 mm × 10 mm	The medial femoral condyle	26 weeks	EPO/BMAC/scaffold
Jagodzinski et al. [69]	14 months	7 mm × 10 mm	The medial or lateral femoral condyles	3 months	Bone marrow derived cell concentrates