Animal Models of Osteochondral Defect for Testing Biomaterials

Table 6

Examples of studies using sheep osteochondral defect models.

Authors	Age	Defect size (diameter × depth)	Location	Endpoint	Material tested
Schlichting et al. [70]	2 and 3 years	7.3 mm × 10 mm	The femoral condyles	3, 6 months	Stiff scaffold
Bernstein et al. [71]	2–4 year	7 mm × 25 mm	The femoral condyles	6, 12, 26, and 52 weeks	β-TCP/chondrocytes
Mohan et al. [72]	>3.5 years	6 mm × 6 mm	MFCs and LFCs	1 year	PLGA/β-TCP
Yucekul et al. [74]	—	8 mm × 10 mm	The lateral condyles	3, 6 and 12 months	PLLA/PCL/β-TCP
Mrosek et al. [75]	—	8 mm × 13 mm	The medial femoral condyle	16 weeks	Trabecular metal with an autologous periosteum graft