In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice

Table 1

Percent parasitemia and suppression of infected mice treated with 80% methanol extract and aqueous extracts of Terminalia brownii in the 4-day suppressive test.

Test substances	Dose (mg/kg/day)	% parasitemia	% suppression	Survival days
Distilled water	0.2 ml	25.5 ± 0.27	0.00	5.8 ± 0.20
Methanol extract	100 mg	17.2 ± 0.29	32.7^a^c^d	8.0 ± 0.00^a
	200 mg	13.5 ± 0.26	47.1^a^b^d	10.8 ± 0.20^a
	400 mg	10.2 ± 0.28	60.2^a^b^c^g	12.8 ± 0.20^a^e
Aqueous extract	100 mg	18.9 ± 0.49	25.9^a^f^g	6.8 ± 0.20^a
	200 mg	15.5 ± 0.22	39.4^a^e^g	7.0 ± 0.00^a
	400 mg	12.5 ± 0.27	51.1^a^d^e^f	7.4 ± 0.24^a
Chloroquine	25 mg	0.0 ± 0.00	100.0^a^b^c^d^e^f^g	28.0 ± 0.00^a^b^c^d^e^f^g

Values are presented as M ± SEM; n = 5; ; a = compared to negative control; b = compared to 80% methanol extract 100 mg; c = compared to 80% methanol extract 200 mg; d = compared to 80% methanol extract 400 mg; e = compared to aqueous extract 100 mg; f = compared to aqueous extract 200 mg; g = compared to aqueous extract 400 mg.