In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice

Table 2

Body weight of infected mice treated with 80% methanol and aqueous extracts of Terminalia brownii in the 4-day suppressive test.

Test substances	Dose (mg/kg/day)	Pretreatment body weight	Posttreatment body weight	Percentage change %
Distilled water	0.2 ml	27.1 ± 1.17	23.0 ± 1.08	−1.3
Methanol extract	100 mg	26.2 ± 0.67	24.2 ± 0.70	−0.4^a
	200 mg	26.9 ± 0.53	26.9 ± 0.58	+0.2^a^c
	400 mg	26.9 ± 1.00	27.1 ± 1.09	+0.6^a^c
Aqueous extract	100 mg	29.1 ± 0.40	26.4 ± 0.43	−0.6^a
	200 mg	30.5 ± 0.34	28.2 ± 0.33	−0.3^a
	400 mg	28.9 ± 0.62	26.7 ± 0.64	−0.4^a
Chloroquine	25 mg	26.9 ± 0.80	29.8 ± 0.80	+2.1^a^bc

Values are presented as M ± SEM; n = 5; ; a = compared to negative control; b = compared to 80% methanol extract; c = compared to aqueous extract.