Modulatory Effect of Probiotics on Proinflammatory Cytokine Levels in Acrylamide-Treated Rats

Table 1

Effect of treatment with the probiotic on the serum levels of IL-1β at different times and across all study groups.

Groups	IL-1ß0 (pg/mL)	IL-1ß15 (pg/mL)	IL-1ß30 (pg/mL)	value
1 (acrylamide)	57.88 ± 5.88	70.39 ± 25.59	45.14 ± 6.52	0.51^a, 0.275^b, 0.51^c
2 (acrylamide + LD)	60.04 ± 6.51	72.92 ± 12.53	26.06 ± 2.66	0.275^a, 0.05^b, 0.05^c
3 (acrylamide + HD)	43.72 ± 4.56	37.50 ± 15.33	29.94 ± 3.65	0.513^a, 0.05^b, 0.82^c
4 (control)	63.05 ± 7.17	70.42 ± 13.54	23.87 ± 4.01	0.82^a, 0.05^b, 0.05^c
value	0.94	0.46	0.03	—

Data are presented as mean ± SEM (standard error of the mean). LD: low dose of probiotics; HD: high dose of probiotics; bold values show a significant difference (). ^aComparison between days 0 and 15 (t-test). ^bComparison between days 0 and 30 (t-test). ^cComparison between days 15 and 30 (t-test). Comparison of 4 groups (one-way ANOVA).